Decreased Antioxidant Capacity in Corn Farmers Occupationally Exposed to the Mixture of Herbicides
Keywords:8-isoprotane, Glyphosate, Paraquat, Total antioxidant capacity (TAC)
Background: The application of herbicides has been a common practice in worldwide agriculture, mainly
with the goal to increase efficacy of weed control. So, most farmers faced a greater risk of herbicide
exposure to develop adverse health effects from oxidative stress-induced herbicides. The aim of this study
is to determine the urinary total antioxidant capacity (TAC) and 8-isoprostane levels in farmers using the
mixture of herbicides in Long District, Phrae Province, Thailand.
Methods: Ninety-three participants were recruited. The spot urine samples (pre- and post-work) were
collected. The urinary TAC was determined using ABTS radical scavenging assay. The urinary 8-isoprostane
level was investigated by commercial ELISA kit.
Results: Most farmers worked on a farm during 1-5 h/day. Fifty-five percents of participants used the
mixture of herbicide while working between glyphosate and paraquat as well as glyphosate and 2,4-D. The
urinary TAC levels in pre-work urine sample of farmers applied combining herbicides were significantly
higher than that level in their post-work urine sample. However, there was no significant difference between
pre- and post-work urinary 8-isoprostane in farmers applied combining herbicides.
Conclusion: The results suggest that occupational exposure to mixture of glyphosate herbicides plus paraquat
or 2,4-D could induce abnormal oxidative stress value especially antioxidant defense among agricultural
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