Synthesis of Diimidazole Has Pyrazole, Isoxazole and Pyrimidine Derivatives and Evaluation as Antibacterial

Authors

  • Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2

Keywords:

pyrazole, isoxazole, imidazole, thiopyrimidine

Abstract

New diimidazole contains pyrazole , isoxazole and thiopyrimidine were synthesized by using simple methods. All compounds were synthesized by using hippuric acid (1) as stating material which was obtained from benzoyl and glycine with. pyrazole derivatives (6a – b ) was obtained from reaction (5a – b) with hydrazine hydrate while reaction of (5a – b )with hydroxyl amine isoxazole derivatives (7a – b) were obtained ,finally reaction of thiourea was reacted with 5a – b thiopyrimidine derivatives were get (8a –b ) . FTIR and 1HNMR spectra were used to characterized derivatives several bacterial species like Pseudomonas aeruginosa , Staphylococcus aureus, and Acinetobacter baumanii were used to tested antibacterial activity

Author Biography

Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2

1Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq,
2Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq

Published

2020-01-16

How to Cite

Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2. (2020). Synthesis of Diimidazole Has Pyrazole, Isoxazole and Pyrimidine Derivatives and Evaluation as Antibacterial. Indian Journal of Forensic Medicine & Toxicology, 14(1), 1048-1052. Retrieved from http://medicopublication.com/index.php/ijfmt/article/view/194