Influence of Carcinogenic Substance (7, 12 Dimethylbenz [A] Anthracene (DMBA)) on Tissue, Hematology Character and Enzyme Activity in Rat

Authors

  • Abdulridha Mohammed Al-Asady 1, Intisar Kadhum Ghaleb2, Abeer Muhammed ali Jasim Alnasrawi 3, Thoalffakar A. ALhamed4

Keywords:

7,12-dimethylbenz[a]anthracene (DMBA); Blood parameters; Antioxidant enzyme ; MDA ; Rat.

Abstract

This study designed to investigate the effects of 7,12 dimethylbenz [a] anthracene (DMBA)on some blood parameters and hepatic histopathology in rats and antioxidant enzyme. twenty female Wistar albino rats, weighing 180–200 g, were randomly divided into two group 1- DMBA group (positive group) who received 20 mg DMBA/kg body weight/ (single Douse) 2-Control group (negative group) doesn’t receive any item. The animals in these groups were sacrificed at the end of the 90 days:The histological structure of the liver tissues in the control group was normal. the liver exhibited hydropic degeneration and coagulation necrosis in hepatocytes, severe dilation in the sinusoids, congestion in the central and portal regions , DMBA groups, was degenerative and necrotic changes were detected.MDA levels increased in the DMBAgroup , compared to the control group, Antioxidant activity CAT, SOD and GPX, the results showed increased enzyme activity in positive control compared with negative groups , ,the hematological parameter was increase in WBC, PLT, GRA, and LYM and decrease in RBC value .

Author Biography

Abdulridha Mohammed Al-Asady 1, Intisar Kadhum Ghaleb2, Abeer Muhammed ali Jasim Alnasrawi 3, Thoalffakar A. ALhamed4

1College of Nursing, University of Warith Al-anbiya’a , Iraq, Assist. Lecturer, 2Department of biology, college of science, university of kerbala , Iraq,Assist. Lecturer, 3 Department of Clinical Laboratories, College of Applied Medical Science, University of Kerbala, Iraq, 4 College of Nursing, University of Warith Al-anbiya’a , Iraq

Published

2020-01-16

How to Cite

Abdulridha Mohammed Al-Asady 1, Intisar Kadhum Ghaleb2, Abeer Muhammed ali Jasim Alnasrawi 3, Thoalffakar A. ALhamed4. (2020). Influence of Carcinogenic Substance (7, 12 Dimethylbenz [A] Anthracene (DMBA)) on Tissue, Hematology Character and Enzyme Activity in Rat. Indian Journal of Forensic Medicine & Toxicology, 14(1), 1255-1259. Retrieved from http://medicopublication.com/index.php/ijfmt/article/view/250