Synthesis of Diimidazole Has Pyrazole, Isoxazole and Pyrimidine Derivatives and Evaluation as Antibacterial

Authors

  • Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2

DOI:

https://doi.org/10.37506/ijfmt.v14i2.2914

Keywords:

pyrazole, isoxazole, imidazole, thiopyrimidine

Abstract

New diimidazole contains pyrazole , isoxazole and thiopyrimidine were synthesized by using simple methods . All compounds were synthesized by using hippuric acid (1) as stating material which was obtained from benzoyl and glycine with. pyrazole derivatives (6a – b ) was obtained from reaction (5a – b) with hydrazine hydrate while reaction of (5a – b )with hydroxyl amine isoxazole derivatives (7a – b) were obtained ,finally reaction of thiourea was reacted with 5a – b thiopyrimidine derivatives were get (8a –b ) . FTIR and 1HNMR spectra were used to characterized derivatives several bacterial species like Pseudomonas aeruginosa , Staphylococcus aureus, and Acinetobacter baumanii were used to tested antibacterial activity

Author Biography

Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2

1 Department of Biology, 2Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq

Published

2020-04-29

How to Cite

Sahar Abdullah Kadham.1, Abdul Jabar Kh. Atia2. (2020). Synthesis of Diimidazole Has Pyrazole, Isoxazole and Pyrimidine Derivatives and Evaluation as Antibacterial. Indian Journal of Forensic Medicine & Toxicology, 14(2), 581-585. https://doi.org/10.37506/ijfmt.v14i2.2914