Genotype and Haplotype of HLA- Class II in Type I and Type II Diabetes Mellitus in Iraqi Patients
Keywords:Type II diabetic, Type I diabetes, HLA classII, genotype, haplotype.
Background: Diabetes is one of the common complicated disease associated with multiple influenced factors, immunological serological and molecular factors play a great role in susceptibility and diagnosis of this disease. HLA genotyping were reported to have an influencing in both types of diabetes. Aim: The current study was conducted to investigate the association of human leukocytes genotypes in Diabetes patients. Method: Case-control study enrolled 225 blood samples collected from patient attended to the Marjan Teaching Hospital- Hilla and 25 apparently healthy from October 2018 to May 2019. Class II HLA genotyping was performing for 60 patients with diabetes mellitus and 25 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D and T1ID was set up according to American Diabetes Association criteria. Results: both types of diabetes were significantly associated with HLA-DR3. Associations were also observed with HLA –DQA105:01, the appearance of these two alleles differs in both TID and TIID . Conclusion. Certain HLA class II alleles, haplotypes, and genotypes have related to diabetes mellitus so it can be dependent as a genetic marker for susceptibility of this disease in Iraq.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions