Antimicrobial Activity and Characterization of Some Oxazole, Thiazol and Quinoline

Authors

  • Amjad Gali. Eliwi1, Safaa. Abdul-Hameed. Dadoosh1, Zainab Z. Mohammed Ali1, Abdul Jabar Kalaf Atia1, Iman Rajab Mohammed1, Zaman Ahmed. Hussein1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.2944

Keywords:

:1,3 oxazole, chalcone, thiazole, pyrimidine, quinolone, antimicrobial activity

Abstract

New Heterocyclic compounds derivatives comprising 1,3-oxazole, chalcone ,thiazole, pyrimidine, quinolone moieties are reported. New derivatives of Quinazolin-4 (3H)-one ring comprising Schiff’s bases,(1,3,4Thiadiazole),(1,3,4-Oxadiazole) and (1,2,4-Triazole), Thiaurease moieties are reported. Compounds (1), (2) and (5) were synthesized by reaction of benzoyl chloride with urea , thiourea and anthranilic acid respectively , then compounds (1)and (2) were converted into(3a-c) and (4a-c) derivatives. While compound (5) reaction with urea to convert to compound (6) which was converted to (7a-c) . chalcone derivatives (9a,b ) were readily obtained by reaction of compound (8) with different aldehydes, Compounds (9a , b) were converted into (10a,b) and (11a,b) The structure of these compounds has been established on the basis of their spectral data FTIR and 1HNMR. These compounds were tested for invitro antibacterial activity against Escherichia coli, Sepidermidis, S.aureusand Klebseillastandard methods. These synthesized compounds have been shown moderate to good antibacterial activity.

Author Biography

Amjad Gali. Eliwi1, Safaa. Abdul-Hameed. Dadoosh1, Zainab Z. Mohammed Ali1, Abdul Jabar Kalaf Atia1, Iman Rajab Mohammed1, Zaman Ahmed. Hussein1

1Department of Chemistry, College of Science-University of AL-Mustansiriyah- Baghdad-Iraq

Published

2020-04-29

How to Cite

Amjad Gali. Eliwi1, Safaa. Abdul-Hameed. Dadoosh1, Zainab Z. Mohammed Ali1, Abdul Jabar Kalaf Atia1, Iman Rajab Mohammed1, Zaman Ahmed. Hussein1. (2020). Antimicrobial Activity and Characterization of Some Oxazole, Thiazol and Quinoline. Indian Journal of Forensic Medicine & Toxicology, 14(2), 709-715. https://doi.org/10.37506/ijfmt.v14i2.2944