Evaluation Protective Role of Salvia officinalis Silver Nanoparticles Against Toxic Effect of Bisphenol a in Female Rats
Keywords:Salvia officinalis , Bisphenol A , FSH , LH
Bisphenol A ( BPA ) is chemical compound found in the environment and used in the manufacturing of plastic , which known as deleterious part of different body parts . Salvia officinalis ( SO ) which is perennial round shrub in the family of Labiatae /Lamiaceae. It’s has potent antioxidant and anti-inflammatory effects . The present study was conducted to evaluate the protective role of SO as nanoparticles against harmful effect of BPA in female rats . Eighteen adult female rats were used and divided equally and randomly into three groups as following : first group received DMSO orally and served as control group while second and third groups were gavaged either with BPA alone or in combination with SOSNP respectively , all the treatments extend 30 days . The result revealed harm effect of BPA by significantly increase the level of estrogen , AST, ALT , ALP , urea and creatinine with significantly reduction in the FSH and LH . SOSNPs show ameliorative effect on all above parameters .
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