Spectrophotometric Determination of Isopropamide Iodide based on Ion-pair Complex Formation with Thymol Blue
Keywords:Isopropamide iodide, spectrophotometry, ion-pair complex, Thymol blue, pharmaceuticals
A simple, accurate, affordable, and rapid spectrophotometric approach has been established for the quantification of the medicinal compound of Isopropamide iodide (ISO) in pharmaceutical preparations. An ion-pair complex which absorbs at 404nm has formed the reaction of the drug and the coloring reagent of Thymol blue (TB) at an acidic medium of pH=4. The calibration curve showed excellent linearity over a quantification range of (1-40 ?g/ml) with an excellent coefficient of correlation (= 0.9993). The examined limit of detection (LOD) was (0.3 ?g/ml) for repeatability of (n= 3). The approach witness no interference of the commonly used excipients in such pharmaceutical formulation that contains Isopropamide iodide. Validation of the method was accomplished by calculating the relative standard deviation (RSD %) and found to be in the range of (1.1938-0.5954). While recovery percentage for (n=3) was (97.4 – 101.4%). The analytical parameters of the method were optimized and were efficaciously applied to the Isopropamide iodide determination in pure form and in the mixture of a tablet form. The approach can be functional for determining other active pharmaceuticals.
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