Effect of High Trace Element Levels in Serum of Women Undergoing Intra-cytoplasmic Sperm Injection (ICSI) on Implantation Rate

Authors

  • Lana Nazar Abdul-Razzaq 1, Khalid Mahdi Salih 2, Bushra Jawad Al-Musawi3.

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3051

Keywords:

Implantation failure .Copper. Zinc. Intra-cytoplasmic Sperm Injection.

Abstract

Objectives: To assess the effects of trace element concentrations in serum on implantation rate in women undergoing ICSI. Study design: Across-sectional study was conducted between March 2018 to April 2019 in Kamal ALSamarai Hospital, center of fertility and IVF. One hundred and seventeen women underwent ICSI using GnRH-antagonist protocol were recruited. Concentration E2, P4 and two trace elements (Cu, Zn, and Cu/ Zn) were measured in serum specimen. Women’s were evaluated in two groups; the study group consisted of patients with successful implantation (n = 21) and women in the second group (n=96) experienced implantation failure. Results: No significant differences were observed in age or BMI between the groups. Serum copper levels were significantly higher differences (P=0.001) in group of failure (198 ± 107?g/dL) than in group of successful implantation (133 ± 46?g/dL), zinc concentrations in group of successful and failure out of the maximum of normal range (137 ± 40?g/dL versus 135 ± 34?g/ dL respectively) but statistically significant differences were did not observed (P?0.05). When we calculated the copper/zinc ratio (Cu/Zn), it was significantly higher differences (P=0.001) in group of failure (1.59 ± 1) than in group of successful (1.03 ± 0.4). In conclusion, we observed that high serum copper concentrations and (high Cu/Zn ratio) are a risk factor for implantation failure.

Author Biography

Lana Nazar Abdul-Razzaq 1, Khalid Mahdi Salih 2, Bushra Jawad Al-Musawi3.

1Assist. Lecturer, Ministry of Education, Baghdad, Iraq, 2Prof. Dr., Department of biology, College of Science -Al- Mustansiriya University, Baghdad, Iraq, 3Ph.D. Kamal AL-Samarrai hospital/Baghdad, Iraq

Published

2020-04-29

How to Cite

Lana Nazar Abdul-Razzaq 1, Khalid Mahdi Salih 2, Bushra Jawad Al-Musawi3. (2020). Effect of High Trace Element Levels in Serum of Women Undergoing Intra-cytoplasmic Sperm Injection (ICSI) on Implantation Rate. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1084-1089. https://doi.org/10.37506/ijfmt.v14i2.3051