Cortisol And Psychological Factors in Etiology of Lichen Planus
Keywords:Lichen Planus, Cortisol, DASS, Stress, Depression, Anxiety
Background and Objectives: Lichen planus is a common chronic inflammatory disease of oral mucosa and skin, whose exact pathogenic mechanisms have not been understood. Cortisol, has been used as an indicator in various psychological evaluation studies. Salivary cortisol measurement is an indicator of free cortisol in human serum and provides noninvasive and easy technique. Aims, evaluation of cortisol levels and psycho-immunity profile in lichen planus patients was done. Using case-control method. Materials and Method: 145 participants were admitted which had been done at dermatological outpatient clinic at Al-Yarmook Teaching Hospital. 32 patients were clinically proven cases of LP, 113 subjects along with age and sex-matched healthy controls. DASS Score questionnaire was administered to evaluate the psychiatric status (depression, anxiety and stress), Saliva samples were collected, and analyzed for cortisol level by using ELISA in study group and 46 of control group. The serum test were examined in 32 for each group using enhanced lanthanide fluoroimmunoassay technique for cortisol. Results: The mean serum and Salivary cortisol level of the LP group showed a very highly significant difference (p=0.001) from the controls in multivariate statistic. The mean of DASS scores and the depression derangement specifically showed a very highly significant difference (p=0.001) from the controls. The stress and anxiety derangement showed high difference but it failed to reach to significant difference from the controls. There is an important association between serum and salivary cortisol concentration. Conclusion: the cortisol and psychiatric factors play a vital role in the pathogenesis of LP and saliva cortisol could be a possible indicator instead of serum cortisol
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions