Determination of Oxidant / Antioxidant Levels in Sheep with Hydatite Cyst in Liver
Keywords:Cystic Echinococcosis, sheep, PON1, ARES, TAS, TOS
The larval form of Echinococcus granulosus, hydatid cyst is an important parasitic zoonosis commonly seen in animals and humans. The aim of this study was to investigate the efficacy of oxidative stress on the pathogenesis of cystic echinococcosis with antioxidant / oxidant status in sheep sera. The material of the study was composed of sheep infected with hydatid cyst and healthy cut in slaughterhouse in Van province. The general health status of the sheep before slaughtering was checked by physical examination and blood samples were taken. After slaughtering, cyst hydatid examination was performed in different organs of the animals. The control group consisted of 25 sheep study cases with positive (fertil cyst) and 15 sheep without any pathological lesion on organ examinations and healthy on physical examination. Blood samples taken from animals infected with healthy and hydatid cysts were transported to the laboratory under appropriate conditions and centrifuged. Total antioxidant / oxidant status, paraoxonase and arylesterase activities were measured by using commercial kits. Compared with cystic echinococcosis group and healthy group, the importance was calculated on the TAS, PON1 activities (P <0.01), TOS, ARES activities differences (P <0.001), It decreases. This may cause tissue necrosis and increased inflammation . Decrease in antioxidant reserves; excessive free radical formation in the ewes with cystic echinococcosis causes deterioration of the normal histological structure of the organ in the cyst.
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