Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients

Authors

  • Mohammed.T. Alaanzy1, Jinan .MJ.Alsaffar2, Ahmed AbdulBari3

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3093

Keywords:

Systemic Lupus erythrmatosus ,Interleukin -17A, Trans forming growth factor-?1, disease activity.

Abstract

The study was done in January – may 2018, For measuring interleukin concentration 17-A and transforming growth factor-?1 in the serum of syst.emic lu.pus erythrmatosus (SLE) female patients(52 female) compared to the control group (36 healthy female). An E?zyme- Link ed Immun?s orbent Assay (ELISA) was used to diagnose both IL-17A and TGF ?1 in SLE patients and control. In case of IL-17A High significant in.crease (P < 0.0001) in SLE patients (38.54 pg / mL) compare d with he althy co.ntrol (20.24 pg / mL) was observed, while in patients with SLE, the transforming growth factor-? was (70.90 pg / mL) compared to healthy control (116.66 pg / mL) (P < 0.0001). To all SLE patients and control, The laboratory features include full blood count ,ery.throcyte sedimentation rate ESR, ,an.d immunological tests like C3,C4,ANA and anti ds-DNA were done. ESR , WBC , ANA and Urea were significantly higher in SLE patient than con trol group (p.value 0.0001, 0.0001, 0.024, 0.0001 respectively) whereas Hemoglobin were significantly lower in SLE Patient than control group (p.value 0.0001) .C3&C4 were lower in SLE patients but with no significance value.

Author Biography

Mohammed.T. Alaanzy1, Jinan .MJ.Alsaffar2, Ahmed AbdulBari3

1Researcher, College of science / University of Baghdad, 2Assist Prof, College of Science / University of Baghdad, 3Senior Specialist Doctor, Ibn Seena Hospital

Published

2020-04-29

How to Cite

Mohammed.T. Alaanzy1, Jinan .MJ.Alsaffar2, Ahmed AbdulBari3. (2020). Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1329-1334. https://doi.org/10.37506/ijfmt.v14i2.3093