Measurement of Interleukin 17a and Transforming Growth Factor-?1 and Its Relation to Disease Activity in Systemic Lupus Erythematosus Patients
Keywords:Systemic Lupus erythrmatosus ,Interleukin -17A, Trans forming growth factor-?1, disease activity.
The study was done in January – may 2018, For measuring interleukin concentration 17-A and transforming growth factor-?1 in the serum of syst.emic lu.pus erythrmatosus (SLE) female patients(52 female) compared to the control group (36 healthy female). An E?zyme- Link ed Immun?s orbent Assay (ELISA) was used to diagnose both IL-17A and TGF ?1 in SLE patients and control. In case of IL-17A High significant in.crease (P < 0.0001) in SLE patients (38.54 pg / mL) compare d with he althy co.ntrol (20.24 pg / mL) was observed, while in patients with SLE, the transforming growth factor-? was (70.90 pg / mL) compared to healthy control (116.66 pg / mL) (P < 0.0001). To all SLE patients and control, The laboratory features include full blood count ,ery.throcyte sedimentation rate ESR, ,an.d immunological tests like C3,C4,ANA and anti ds-DNA were done. ESR , WBC , ANA and Urea were significantly higher in SLE patient than con trol group (p.value 0.0001, 0.0001, 0.024, 0.0001 respectively) whereas Hemoglobin were significantly lower in SLE Patient than control group (p.value 0.0001) .C3&C4 were lower in SLE patients but with no significance value.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions