The Effect of CHOP Chemotherapy Implementation Towards Reduced Global Longitudinal Strain in Non-Hodgkin Lymphoma

Authors

  • Muhammad Perdana Airlanga1, Rochmad Romdoni1, Ami Asharianti2

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3100

Keywords:

Global longitudinal strain, Left ventricular ejection fraction, anthracycline, CHOP chemotherapy

Abstract

Background: Doxorubicin in CHOP regimen is still the golden standard of first-line chemotherapy in patients with NHL (Non-Hodgkin Lymphoma); however, it has enormous cardiotoxicity side-effects. Objective: This study aims to investigate the effect of CHOP chemotherapy implementation towards the GLS reduction in cumulative dosage of doxorubicin ? 100 mg/m. Method: This study was pre experimental analysis with modified cohort. The subjects were observed for 1 month, since the first chemotherapy until 1 week after the second chemotherapy. The echocardiogram procedure with ejection fraction and global longitudinal strain was conducted twice which was before the first chemotherapy and 1 week after the second chemotherapy. Results: The implementation of CHOP therapy with the cumulative dosage of ?100 mg/m2 has resulted in reduced GLS from 19.62% to -18.03%. The reduction of GLS>10% was 40% while the LVEF has not been obtained any reduction > 10%. The case of subclinical left ventricular dysfunctions was attained 16%. Conclusion: The implementation of CHOP chemotherapy with the dosage of ?100mg/m2 has been proved to cause reduced GLS and subclinical left ventricular dysfunctions.

Author Biography

Muhammad Perdana Airlanga1, Rochmad Romdoni1, Ami Asharianti2

1Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya 60285, Indonesia, 2Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, 6025, Indonesia

Published

2020-04-29

How to Cite

Muhammad Perdana Airlanga1, Rochmad Romdoni1, Ami Asharianti2. (2020). The Effect of CHOP Chemotherapy Implementation Towards Reduced Global Longitudinal Strain in Non-Hodgkin Lymphoma. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1353-1358. https://doi.org/10.37506/ijfmt.v14i2.3100