Effect of Metronidazole on Clopidogrel Bisulphate Efficacy in Male Albino Rats

Authors

  • Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3101

Keywords:

Clopidogrel bisulphate, metronidazole, cytochrome CYP3A4, bleeding time

Abstract

The data about this combination effect on platelet function and hematological parameters are sparse, but there is only mention in many medical science websites such as Medscape, there are possible interaction between it, in which metronidazole cause inhibition to cytochrome CYP3A4 which responsible on clopidogrel metabolism, this may put the patients that on clopidogrel bisulphate therapy at risk of clot formation and may be progress, this may occur because clopidogrel is at inactive form and need to activation by cytochrome mention above, so this study was performed in order to achieve the following aims: studying the efficacy of clopidogrel bisulphate on coagulation process by measuring bleeding time when giving clopidogrel alone and in combination with metronidazole and studying the possible effect of two drug alone and in combination on hematological parameters in male albino rats

Author Biography

Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3

1Department of Pharmaceutics, Assistant lecturer, College of Pharmacy, University of Anbar, 2Department of Pharmacology and toxicology, Assistant lecturer, College of Pharmacy- University of Anbar, 3Department of Pharmaceutical Chemistry, Assistant lecturer, College of Pharmacy, University of Anbar

Published

2020-04-29

How to Cite

Saddam Jumaa Nasser1, Muhammed M. Al-Ani2, Mohammad Sinjar Farhan3. (2020). Effect of Metronidazole on Clopidogrel Bisulphate Efficacy in Male Albino Rats. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1359-1363. https://doi.org/10.37506/ijfmt.v14i2.3101