In silico Analysis of “Interferon Beta 1” In some Selected Animal Species

Authors

  • Ashraf Fadhil Jomah1, Sepideh Parvizpour2, Jafar Razmara3

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3128

Keywords:

Interferons, h?ostprote?ctionth, cy?tok?ines, divergence, counterpart.

Abstract

Type I interferons (IFNs), are considered as a main host immune system cytokines effector against infectious virus. In addition to ?i?nnat?eim?munerecep?torbac?teriallig?ands and/or bact?erial infections. Furthermore, th?e development o?f kinds I?F?Ns are a?ls?o triggered, suggesting a wider physiological function f?or those cy?tok?inesi?nhom?eostaisi and h?ostprote?ctionth?an initially expected. Results: To recognize both structural divergence and sequence various bioinformatics methods were used. Initial sequence analysis of IFNß1 showed that they shared with human over 70% similarity and some identity like Rhesus monkey, pig , domestic cat ,for dog. With few exceptions, sequences showed a high degree of sequence preservation. The physicochemical analysis indicated a large developmental difference between humans and others and an estimate of 39% to 42% of hydrophobic residues. Four human mammals house mouse pig Norway rat have various Pfam types. The secondary structure of IFNß1 composed of ran?domco?il, Exv?tendedstr?anda?ndAl?phahe?lix. Conclusions: Depending o?nth?eres?ults collected, which maybe assumed th?at in these mammalian species IFNß1 has the same counterpart, highly retained and functional similarities.

Author Biography

Ashraf Fadhil Jomah1, Sepideh Parvizpour2, Jafar Razmara3

1College of Basic Education,Department of Science, University of Sumer, Rifai, Iraq, 2Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran, 3Department of Computer Science, Faculty of Mathematical Sciences, University of Tabriz, Tabriz, Iran

Published

2020-04-29

How to Cite

Ashraf Fadhil Jomah1, Sepideh Parvizpour2, Jafar Razmara3. (2020). In silico Analysis of “Interferon Beta 1” In some Selected Animal Species. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1452-1457. https://doi.org/10.37506/ijfmt.v14i2.3128