The Effectiveness Comparison of Valproic Acid 500 mg and Amitriptyline 15 mg in Reducing the Frequency of Headache Attack in Patients with Tension-Type Headache
Keywords:valproic acid, amitriptyline, pain, tension-type headache
Background: Tension-type headache (TTH) is the most common headache. Continuous analgesic use can develop into headache caused by drug abuse (medication overused headache); thus, the preventive therapy is necessary. Amitriptyline and valproic acid are drugs reported to reduce the frequency of headache in TTH patients. Objective: To analyze the effectiveness of valproic acid 500 mg and amitriptyline 15 mg in reducing the frequency of headache attack in patients with tension-type headache. Methods: The study applied a Double Blind Randomized Clinical Trial involving 50 TTH patients. The subjects were divided into two groups: amitriptyline 15 mg and valproate acid 500 mg. The period of drug administration was 6 weeks. The variables that were compared were the decreasing frequency of headache and the intensity of the pain. Results: There was no significant difference in the decrease of headache frequency (p = 0.730) and pain intensity (p = 0.430) between the amitriptyline group and valproate acid group. However, each drug effectively decreased the frequency of headache and pain intensity in TTH patients (p = 0.000). Conclusion: There was no significant difference between the effectiveness of valproic acid 500 mg and amitriptyline 15 mg in reducing the frequency of headache in patients with TTH.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions