The Effectiveness Comparison of Valproic Acid 500 mg and Amitriptyline 15 mg in Reducing the Frequency of Headache Attack in Patients with Tension-Type Headache

Authors

  • Elsa Susanti1, Isti Suharjanti1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3143

Keywords:

valproic acid, amitriptyline, pain, tension-type headache

Abstract

Background: Tension-type headache (TTH) is the most common headache. Continuous analgesic use can develop into headache caused by drug abuse (medication overused headache); thus, the preventive therapy is necessary. Amitriptyline and valproic acid are drugs reported to reduce the frequency of headache in TTH patients. Objective: To analyze the effectiveness of valproic acid 500 mg and amitriptyline 15 mg in reducing the frequency of headache attack in patients with tension-type headache. Methods: The study applied a Double Blind Randomized Clinical Trial involving 50 TTH patients. The subjects were divided into two groups: amitriptyline 15 mg and valproate acid 500 mg. The period of drug administration was 6 weeks. The variables that were compared were the decreasing frequency of headache and the intensity of the pain. Results: There was no significant difference in the decrease of headache frequency (p = 0.730) and pain intensity (p = 0.430) between the amitriptyline group and valproate acid group. However, each drug effectively decreased the frequency of headache and pain intensity in TTH patients (p = 0.000). Conclusion: There was no significant difference between the effectiveness of valproic acid 500 mg and amitriptyline 15 mg in reducing the frequency of headache in patients with TTH.

Author Biography

Elsa Susanti1, Isti Suharjanti1

Departement of Neurology, Faculty of Medicine Universitas Airlangga, Surabaya (60131), Indonesia

Published

2020-04-29

How to Cite

Elsa Susanti1, Isti Suharjanti1. (2020). The Effectiveness Comparison of Valproic Acid 500 mg and Amitriptyline 15 mg in Reducing the Frequency of Headache Attack in Patients with Tension-Type Headache. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1536-1540. https://doi.org/10.37506/ijfmt.v14i2.3143