The Association Between Myoglobin, Troponin I, Hfabp and Nt-Probnp Levels with Acute Myocardial Infarction in Patients with Acute Coronary Syndrome

Authors

  • Ime Fransiska Adidharma1, Jusak Nugraha1, Muhammad Aminuddin1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3157

Keywords:

AMI, ACS, myoglobin, cTnI, HFABP, NT-proBNP

Abstract

Introduction: Myocardial infarction is one of the five major manifestations of coronary heart disease. Myoglobin heart markers, Isoenzyme Creatine Kinase-MB (CK-MB), cardiac Troponin I (cTnI) or Troponin T (cTnT), Heart type fatty acid-binding protein (HFABP) and NT-proBNPare currently used in assisting the diagnosis of acute myocardial infarction. The study aimed to analyze the association of cardiac marker examination results of myoglobin, cTnI, HFABP and NT-proBNP with AMIoccurrence on examination I and examination II. Method: This study enrolled33 patients in Installation of Emergency Carewith suspected acute coronary syndrome, from March to August 2013. Serum samples were taken including cTnT, myoglobin, cTnI, HFABP and NT-proBNP. Then, it was further analyzed. Results: There was an association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events. Myoglobin and HFABP wereearly markers for the diagnosis of AMI, the mean levels of both markers was higher at the first examination (<1 hour admitted patients) when compared with 6 hours later after being tested. Essentially, the diagnostic value of both did not differ, only HFABP was more specific than myoglobin. Troponin I showed to be the best choice in the diagnosis of AMI because of the high sensitivity and specificity. Conclusion: An association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events was found. Myoglobin, cTnI, HFABP can be used in diagnosing AMI patients, whereas NT-proBNP is not recommended for the diagnosis of AMI due to its low specificity.

Author Biography

Ime Fransiska Adidharma1, Jusak Nugraha1, Muhammad Aminuddin1

1Department of Clinical Pathology Faculty of Medicine Universitas Airlangga Dr. Soetomo Teaching Hospital Surabaya60285, Indonesia

Published

2020-04-29

How to Cite

Ime Fransiska Adidharma1, Jusak Nugraha1, Muhammad Aminuddin1. (2020). The Association Between Myoglobin, Troponin I, Hfabp and Nt-Probnp Levels with Acute Myocardial Infarction in Patients with Acute Coronary Syndrome. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1620-1627. https://doi.org/10.37506/ijfmt.v14i2.3157