Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy

Authors

  • Inaam Ahmed Ameen1, EmanSaadi Saleh1, Sarah Hashim Mhaibes1, KaledNather Taha2, Dhikra Abdul Hameed Dawood2, Hawaa Salman Kamil2

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3158

Keywords:

inflammation, interleukins, tupe2 diabetes mellitus, HbA1c, hyperglycemia

Abstract

Background: Chronic hyperglycemia causes diabetic nephropathy(DN), which is a typical microvascular complication of type 2 diabetes mellitus. The pathogenesis of DN is not fully understanding. The inflammation may possess a significant role in the progression of DN in diabetic patients. Method: The study accomplished at teaching laboratories of medical city, Baghdad, Iraq.It was included 50uncontrolled diabetic type 2 patients with nephropathy, age range (40 –78) years and 42 controlled diabetics type 2 without nephropathy, age range (35 – 52) years as a control group.The participants divided in to two groups according to HbA1c measurement which is described as follows: < 7.5% of HbA1c describes controlled diabetes, and > 9% of HbA1c describes uncontrolled diabetes. The calculation of the Glomerular filtration rate (GFR) was used to determine the renal function for each participant. A venous blood sample was obtained to estimate HbA1c,fasting serum glucose (FSG), urea, creatinine, interleukin6(IL-6),interleukin-1 beta( IL-1?)and tumor necrosis factor – alpha(TNF- ?. ). Results : Significantly higher serum urea and creatinine levels in uncontrolled diabetic patients with nephropathy than controlled diabetic without nephropathy. The mean of HbA1c of DN group was higher as compare to diabetic control (DC) group, Results of IL-1?, IL-6 and TNF-? exhibits a significant raised level for diabetics with nephropathy, (p< 0.05) for IL-1?, (p< 0.05) for IL-6 and (p< 0.01) for TNF-? . Conclusion :Raised serum levels of TNF- ?, IL-1?and IL-6 in uncontrolled diabetic patients with nephropathy concurrently with raising the average HbA1c in them indicate that the inflammation may have a role in the advancement of DN in diabetic patients with poor glycemic control.

Author Biography

Inaam Ahmed Ameen1, EmanSaadi Saleh1, Sarah Hashim Mhaibes1, KaledNather Taha2, Dhikra Abdul Hameed Dawood2, Hawaa Salman Kamil2

1Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad, Iraq, 2Ministry of Health ? Medical City ? National Center for Educational Laboratories, Baghdad, Iraq

Published

2020-04-29

How to Cite

Inaam Ahmed Ameen1, EmanSaadi Saleh1, Sarah Hashim Mhaibes1, KaledNather Taha2, Dhikra Abdul Hameed Dawood2, Hawaa Salman Kamil2. (2020). Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1628-1632. https://doi.org/10.37506/ijfmt.v14i2.3158