Diagnostic test of Brief Peripheral Neuropathy Screen as Distal Sensory Polyneuropathy-HIV Diagnostic Tool

Authors

  • Joko Rudyono1, Mudjiani Basuki1, Erwin Astha Triyono2

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3169

Keywords:

Diagnostic testing, DSP-HIV, Brief peripheral neuropathy screen (BPNS), NCS examination

Abstract

Distal sensory polyneuropathy (DSP) is the most common human immunodeficiency virus (HIV)-associated peripheral neuropathy with a prevalence of 30-67%. Brief peripheral neuropathy screen (BPNS) examination is a non-invasive, fast, cheap, easy-to-do diagnostic method, and one of the clinical tools that can be used to diagnose HIV-DSP. This study to assess the BPNS diagnostic test as a DSP diagnostic tool in HIV patients. The cross-sectional study was conducted on HIV patients that allegedly having DSP. All subjects were examined by BPNS and nerve conduction study (NCS), then the results were analyzed by chi-square test of a 2x2 Table. There were 42 subjects enrolled in this study. The mean patients were 38.88±8.62 years and most of the male patients were 24 subjects (57.14%). Most of the patients had high school education by 20 (47.61%) subjects and did not take anti-retroviral (ARV) by 18 (42.85%) subjects. Most of the research subjects conducted BPNS disturbed examination by 27 (64.28%) subjects and examination of NCS obtained positive DSP by 30 (71.4%) subjects. The obtained sensitivity of 83% BPNS, 83% specificity, 93% positive predictive value, the negative predictive value of 67%, a positive likelihood ratio of 5.00, and a negative likelihood ratio of 0.20. BPNS examination with 83% sensitivity and 83% specificity can be used as a DSP diagnostic tool in HIV patients.

Author Biography

Joko Rudyono1, Mudjiani Basuki1, Erwin Astha Triyono2

1Department of Neurology, Faculty of Medicine, Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60285, Indonesia, 2Departent of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya 60131, Indonesia

Published

2020-04-29

How to Cite

Joko Rudyono1, Mudjiani Basuki1, Erwin Astha Triyono2. (2020). Diagnostic test of Brief Peripheral Neuropathy Screen as Distal Sensory Polyneuropathy-HIV Diagnostic Tool. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1670-1675. https://doi.org/10.37506/ijfmt.v14i2.3169