The Effectiveness Comparison of Desloratadine and Loratadine in Reducing Total Nasal Symptom Score and the Level of Interleukin 4 in the Nasal Secretions of Allergic Rhinitis Patients

Authors

  • Luh Putu Dhena Purwaningsih1, Dwi Reno Pawarti1, Bakti Surarso1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3183

Keywords:

Desloratadine, loratadine, total nasal symptom score, interleukin 4, allergic rhinitis. Coresponding

Abstract

Background: Allergic rhinitis (AR) is a common atopic disease; however, the available therapy has limitation in the usage and its success rate. Desloratadine has a role as an alternative allergic rhinitis therapy to eliminate the overall symptoms of AR and reduce IL-4 level in nasal secretions. Method: This study was double-blind randomised clinical trial with pre-post test design. The data was analyzed by using independent sample t-test. There were 24 AR patients divided into 2 therapy groups which were study group (desloratadine) and control group (loratadine). The evaluation based on SGHT and IL-4 in nasal secretions was conducted pre and post 15 days of therapy. Results: The present study that was conducted on July-October 2016 showed significant difference in the average percentage of reduced TNSS in desloratadine group compared to loratadine group (p=0.000). The comparison of reduced level of IL-4 in nasal secretions between desloratadine and loratadine group was indicated insignificantly different. Conclusion: Reduced TNSS in desloratadine group was higher than in loratadine group. Also, there was no difference in decreased level of IL-4 in nasal secretions.

Author Biography

  • Luh Putu Dhena Purwaningsih1, Dwi Reno Pawarti1, Bakti Surarso1

    1Department of Otolaryngology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, 60285, Indonesia

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Published

2020-04-29

How to Cite

The Effectiveness Comparison of Desloratadine and Loratadine in Reducing Total Nasal Symptom Score and the Level of Interleukin 4 in the Nasal Secretions of Allergic Rhinitis Patients. (2020). Indian Journal of Forensic Medicine & Toxicology, 14(2), 1711-1716. https://doi.org/10.37506/ijfmt.v14i2.3183