The Effectiveness Comparison of Desloratadine and Loratadine in Reducing Total Nasal Symptom Score and the Level of Interleukin 4 in the Nasal Secretions of Allergic Rhinitis Patients

Authors

  • Luh Putu Dhena Purwaningsih1, Dwi Reno Pawarti1, Bakti Surarso1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3183

Keywords:

Desloratadine, loratadine, total nasal symptom score, interleukin 4, allergic rhinitis. Coresponding

Abstract

Background: Allergic rhinitis (AR) is a common atopic disease; however, the available therapy has limitation in the usage and its success rate. Desloratadine has a role as an alternative allergic rhinitis therapy to eliminate the overall symptoms of AR and reduce IL-4 level in nasal secretions. Method: This study was double-blind randomised clinical trial with pre-post test design. The data was analyzed by using independent sample t-test. There were 24 AR patients divided into 2 therapy groups which were study group (desloratadine) and control group (loratadine). The evaluation based on SGHT and IL-4 in nasal secretions was conducted pre and post 15 days of therapy. Results: The present study that was conducted on July-October 2016 showed significant difference in the average percentage of reduced TNSS in desloratadine group compared to loratadine group (p=0.000). The comparison of reduced level of IL-4 in nasal secretions between desloratadine and loratadine group was indicated insignificantly different. Conclusion: Reduced TNSS in desloratadine group was higher than in loratadine group. Also, there was no difference in decreased level of IL-4 in nasal secretions.

Author Biography

Luh Putu Dhena Purwaningsih1, Dwi Reno Pawarti1, Bakti Surarso1

1Department of Otolaryngology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, 60285, Indonesia

Published

2020-04-29

How to Cite

Luh Putu Dhena Purwaningsih1, Dwi Reno Pawarti1, Bakti Surarso1. (2020). The Effectiveness Comparison of Desloratadine and Loratadine in Reducing Total Nasal Symptom Score and the Level of Interleukin 4 in the Nasal Secretions of Allergic Rhinitis Patients. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1711-1716. https://doi.org/10.37506/ijfmt.v14i2.3183