Comparison of Saffron versus Fluoxetine in Treatment of Women with Premenstrual Syndrome: A Randomized Clinical Trial Study

Authors

  • Mohammad Nemat-Shahi1, Atefeh Asadi2, Mahbobeh Nemat-Shahi3, Davood Soroosh4, Shakiba Mozari5, Hamidreza Bahrami-Taghanaki 6, Mahsa Mehrpour7

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3191

Keywords:

Saffron, fluoxetine, premenstrual syndrome

Abstract

Background: Premenstrual syndrome (PMS) is a set of physical and psychological symptoms such as mood disability, breast tenderness, food craving, fatigue, and depression. Fluoxetine and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) usually are being administered for these patients. This study aimed to evaluate the effect of saffron plant in terms of its anti-inflammatory and anti-depressant effects compared to fluoxetine. Materials and Method: This study was a three-blind clinical trial that was carried out on working women and their relatives. Firstly, 164 patients with the premenstrual syndrome were selected, and they were randomly divided into two 82-person groups, including those who received fluoxetine and those who received saffron. Next, both groups were treated for two months. The data were collected in two stages through a self-designed questionnaire (on day 5 of menstrual cycle) and validated questionnaires of PRISM and Beck at the end of the period. Results: It was indicated that similar to fluoxetine, the use of saffron in PMS reduced the symptoms such as abdominal bloating, depression, and mood swing, but the latter could better relieve the breast and abdominal pain than fluoxetine. Conclusion: It was concluded that the use of medicinal herbs such as saffron could be effective in reducing the symptoms and they might cause fewer side effects than chemical drugs.

Author Biography

Mohammad Nemat-Shahi1, Atefeh Asadi2, Mahbobeh Nemat-Shahi3, Davood Soroosh4, Shakiba Mozari5, Hamidreza Bahrami-Taghanaki 6, Mahsa Mehrpour7

1Assistant Professor of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences, 2General practitioner, Deputy of Health of Sabzevar University of Medical Sciences, Department of Labor, Sabzevar, Iran, 3Assistant professor, Department of Social Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran, 4Assistant professor, Department of Forensic Medicine and Poisoning, Faculty of Medicine, Sabzevar University of Medical Sciences,5Assistant Professor of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran, 6Associate professor, Department of Complementary and Chinese Medicine, Persian and Complementary Medicine Faculty, Mashhad University of Medical Sciences, Mashhad, Iran, 7Ph.D. Student of Iranian Traditional Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Published

2020-04-29

How to Cite

Mohammad Nemat-Shahi1, Atefeh Asadi2, Mahbobeh Nemat-Shahi3, Davood Soroosh4, Shakiba Mozari5, Hamidreza Bahrami-Taghanaki 6, Mahsa Mehrpour7. (2020). Comparison of Saffron versus Fluoxetine in Treatment of Women with Premenstrual Syndrome: A Randomized Clinical Trial Study. Indian Journal of Forensic Medicine & Toxicology, 14(2), 1760-1765. https://doi.org/10.37506/ijfmt.v14i2.3191