Genetics Risk Factors and Progression of Renal Failure
Keywords:MYH9 SNP, renal failure, allele distribution and genotyping
Objective: “MYH9 gene” is “expressed” in “kidney, platelets and liver and in lesser amounts in the thymus, spleen, and intestine”, its responsible for encoding a protein called “non muscle myosin heavy chain”. To evaluate the role of MYH9 SNP on developing of renal failure. Method :This study depending on “methodology of Case-control study”, subjects involved were one hundred as patients and control; 50 “patients” complaining renal failure and 50 apparently healthy controls. DNA was extracted from venous blood. The “MYH9 gene polymorphisms” were recognized by applying the procedure of (“PCR-RFLP”). Result :Genotype at rs4821480 in patients with RF: finding that obtained were TT (59%), GT (34%), and GG (6.0%) and for control TT (45%) GT (40%) ,GG(15%). This analysis of data indicated the TT genotype homozygote at rs4821480 convenes independently a threating of RF than does the GT and GG genotypes. a variation in the genotype at rs3752462 was shown in patients with RF: CC (4.8%), CT (73.2%), and TT (22.0%). Conclusion :The outcomes indicate that the CT genotype at rs3752462 confers independently a risk factor of RF than those of TT and CC genotypes. There is no significant correlation between distribution of alleles and age, sex, resident, jobs, smoking habit, family history, body mass index (BMI), and medical history (P>0.05).
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