Histopathological Assessment of Hepato-Nephrotoxicity Induced by Nano Copper Particles in Adult Male Albino Rats and the Potential Protective Effect of Alpha Lipoic Acid: A Chronic Study

Authors

  • Rabab Abdulmoez Amin Eltokhy1, Mervat Hamdy Abdelsalam1, Eman Abdelfattah Elzoheiry1, Marwa Issak Mohamed1, Laila Ahmed Rashed2 and Reham Shehab Elnemr3.

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3252

Keywords:

Copper nanoparticles, Nanotoxicity, Hepatotoxicity, Nephrotoxicity, Histopathology

Abstract

Background: Copper nanoparticles (CNPs) have unique physical and chemical properties for this reason it was widely used in various medical and non-medical applications. This study aimed to study the toxic effect of copper nanoparticles on liver and kidney through histopathological examination of liver and kidney tissues and if there is improvement of hepato-nephrotoxicity after cessation of exposure and to study the potential protective effect of alpha lipoic acid (ALA) against hepato-nephrotoxicity induced by copper nanoparticles. Finding: Histopathological examination of liver and kidney tissues in rats received CNPs showed significant alteration, cessation of exposure can cause slight improvement and ALA can cause significant improvement. Conclusion: Copper Nanoparticles have hepato-nephrotoxic effect and ALA can be safely used as a protective agent against CNPs toxicity.

Author Biography

Rabab Abdulmoez Amin Eltokhy1, Mervat Hamdy Abdelsalam1, Eman Abdelfattah Elzoheiry1, Marwa Issak Mohamed1, Laila Ahmed Rashed2 and Reham Shehab Elnemr3.

1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt. 2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Kasr Alainy Street, Cairo, 11562, Egypt, 3Department of Pathology, Faculty of medicine, Fayum university, Fayum, Egypt.

Published

2020-04-29

How to Cite

Rabab Abdulmoez Amin Eltokhy1, Mervat Hamdy Abdelsalam1, Eman Abdelfattah Elzoheiry1, Marwa Issak Mohamed1, Laila Ahmed Rashed2 and Reham Shehab Elnemr3. (2020). Histopathological Assessment of Hepato-Nephrotoxicity Induced by Nano Copper Particles in Adult Male Albino Rats and the Potential Protective Effect of Alpha Lipoic Acid: A Chronic Study. Indian Journal of Forensic Medicine & Toxicology, 14(2), 2041-2048. https://doi.org/10.37506/ijfmt.v14i2.3252