Histopathological Assessment of Hepato-Nephrotoxicity Induced by Nano Copper Particles in Adult Male Albino Rats and the Potential Protective Effect of Alpha Lipoic Acid: A Chronic Study
Keywords:Copper nanoparticles, Nanotoxicity, Hepatotoxicity, Nephrotoxicity, Histopathology
Background: Copper nanoparticles (CNPs) have unique physical and chemical properties for this reason it was widely used in various medical and non-medical applications. This study aimed to study the toxic effect of copper nanoparticles on liver and kidney through histopathological examination of liver and kidney tissues and if there is improvement of hepato-nephrotoxicity after cessation of exposure and to study the potential protective effect of alpha lipoic acid (ALA) against hepato-nephrotoxicity induced by copper nanoparticles. Finding: Histopathological examination of liver and kidney tissues in rats received CNPs showed significant alteration, cessation of exposure can cause slight improvement and ALA can cause significant improvement. Conclusion: Copper Nanoparticles have hepato-nephrotoxic effect and ALA can be safely used as a protective agent against CNPs toxicity.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions