Association between Genetic Polymorphism of 5-HTTLPR, and SGOT, SGPT and Catalase with Alcoholism of Iraqi People
Keywords:SLC6A4, 5-HTTLPR, SGOT, SGPT, catalase.
A case- control study on the relationship of 5-HTTLPR gene polymorphism with alcohol abuse among Iraqi individuals was conducted during period from December 2018 to June 2019. DNA was extracted from the blood samples of the study subjects. The genetic polymorphism analysis was conducted by Restriction Fragment Length Polymorphism (RFLP-PCR) for SLC6A4 gene. The results raveled that the odd ratio for the LL genotype was 1.697 indicating that homo mutant genotype were at higher risk for alcoholism than the wild type SS. This result showed that L allele frequency was (0.78) in alcoholism group and (0.53) in control group whereas S allele frequency was (0.22) in the alcoholism group and (0.47) in the control group. So, the results showed there was a significant difference in allele frequencies of SLC6A4gene between case and control (P<0.01; OR=1.697; 95% CI=0.86-1.64). There was a significant positive correlation between the SGOT activity and the genotype of 5-HTTLPR (SS, SL, LL).Additionally, there was a significantly increased level of liver enzymes (GOT and GPT) and catalase in serum samples of alcoholic males compared with non-alcoholic males.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions