Sensitive Simultaneous Estimation of Atorvastatin. Ca in Pure and Dosage Forms Via Developed CFIA Using 1,2 Naphthoquinone-4-Sulfonate as a Suitable Organic Agent
Keywords:Atorvastatin calcium; 1,2-Naphthoquinone-4-sulfonate, sodium hydroxide; Pharmaceutical formulation; CFIA/merging zones technique.
Objectives: A sensitive visible spectrophotometric method and FIA/merging zones technique was developed for the determination of atorvastatin calcium in pure material and tablet dosage form. Method: Atorvastatin calcium has a free carboxylic moiety in its structure, which when being deprotonated in basic medium facilitates associated the reagent with the drug. This method was based on the formation of red colored chromogen of drug with 1,2-Naphthaquinone-4-sulfonate(NQS) in basic medium (NaOH). The absorbance of the chromogens was measured at their respective wavelengths of maximum absorbance against the corresponding reagent blank Results: The red colored product is directly completed in basic medium and exhibits maximum absorption at 525 nm. Different factors affecting the formation of the product and optimized in order to obtain the best conditions for the experiment and its stability were studied. Method validation was done over a concentration range of 2-10 and 1-20 ?g/mL for batch and FIA method respectively.
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