A Histological and Histochemical Study on Olfactory Bulbs to Detection Amyloid Protein Depositions by Congo-Red and Routine Staining Techniques
Keywords:Histology, Histochemistry, Congo red, Amyloid ,Granular cells, Mitral cells and olfactory bulbs.
In this study, histological and histochemical techniques were used to examine olfactory bulbs in the albino rat male. Thirty male albino rats were split into three age groups (10 animals each) in the current research: Group I: consider as a control group, including adult animals aged 3 months .Group II: include animals aged 6 months. Group III: include animals aged 12 months. The histological architecture of the layers of olfactory bulbs and their main cells was identified by using H & E staining techniques, meanwhile the composition of each layer in albino rat was evident. In the glomerular and mitral cell layer of group III, olfactory bulbs showed reduced neural density. Modified staining with Congo - red was conducted for histochemical studies. Compacted amyloid cores were found in group III animals’ olfactory bulbs, while dispersed amyloid cores were found in group II&III olfactory bulbs’ cortex. The present study adds to our knowledge of the impact of amyloid protein on olfactory bulbs and their prospective neurodegeneration involvement.
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