Comparison of Clinical Severity Improvement Degree between Acute Thrombotic Stroke Patients with Low and High Matrix Metalloproteinase-9 Levels

Authors

  • Muhamad Hamdan1, Hendro Susilo, Paulus Sugianto1, A. Firdaus Sami1, Mohammad Saiful Ardhi1, Sita Setyowatie1

DOI:

https://doi.org/10.37506/ijfmt.v14i2.3387

Keywords:

Acute thrombotic stroke, MMP-9, NIHSS Level

Abstract

Background: Stroke is a cause of disability and dependency in both humanity and economic. Studies on the association of Matrix metallopeptidase 9 (MMP-9) levels with improved clinical severity are currently limited. Objectives: To determine the improvement of clinical severity in acute thrombotic stroke patients with high and low MMP-9 levels. Methods: Patients acute thrombotic stroke were grouped into low and high MMP-9 levels. MMP-9 levels were considered low when <840 ng/mL and high when ?840 ng/mL. Clinical severity improvement was assessed using the ?NIHSS scale. Results: Eighty subjects were enrolled that consists of clinical severity improved patients with lower MMP9 (37.9%) that higher than high MMP-9 (21.6%). This difference was not statistically significant (p = 0.115). Conclusion: There was no difference in clinical severity improvement in patients with acute thrombotic stroke with low MMP-9 levels in blood serum compared to high MMP-9 levels.

Author Biography

Muhamad Hamdan1, Hendro Susilo, Paulus Sugianto1, A. Firdaus Sami1, Mohammad Saiful Ardhi1, Sita Setyowatie1

1Department of Neurology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital Surabaya, 60285 Indonesia

Published

2020-04-29

How to Cite

Muhamad Hamdan1, Hendro Susilo, Paulus Sugianto1, A. Firdaus Sami1, Mohammad Saiful Ardhi1, Sita Setyowatie1. (2020). Comparison of Clinical Severity Improvement Degree between Acute Thrombotic Stroke Patients with Low and High Matrix Metalloproteinase-9 Levels . Indian Journal of Forensic Medicine & Toxicology, 14(2), 2385-2390. https://doi.org/10.37506/ijfmt.v14i2.3387