The Diagnostic Role of Anti-Human Salivary Gland Protein-1 (anti-SP1) in the Early Detection of Primary Sjogren’s Syndrome in Some Iraqi Patients
Keywords:primary Sjogren’s syndrome, anti-salivary gland protein-1 (anti-SP1), sicca symptoms
Background: Primary Sjogren’s syndrome (pSS) is a chronic disorder described by its immune devastation to the salivary and lacrimal glands. The detection of pSS is complicated especially at the early stage. Thus, the emergence of novel markers preceding the conventional diagnostics for early detection of pSS before its aggravation is required.Objective: This study purposed to reveal the possible use of anti-SP1 as a beneficial indicator for early revelation of pSS in some Iraqi patients.Methods: Eighty-seven Iraqi patients (42 and 45 patients with newly diagnosed pSS and idiopathic sicca symptoms, respectively) enrolled in this study between February 2018 to July 2019. The diagnosis of pSS reliant on AECG and ACR criteria. All patients were assessed for RF, ANA, anti-Ro/SSA, and anti-SP1 by ELISA.Results: A greater prevalence of anti-SP1 was shown in pSS patients than control patients. Anti-SP1positive pSS patients revealed significant shorter sicca duration with lowered Schirmer’s test and USFR, and predominantANA and anti-Ro. Anti-SP1 evinced positive correlations with disease duration, ANA, and anti-Ro,alsonegative correlations with Schirmer’s test and USFR. Higher sensitivity (92.9%) and specificity (95.6%) of anti-SP1 in pSS patients than other diagnostic parameters.Conclusion: Despite small sample size, anti-SP1 still be a dependable marker for diagnosis of pSS at the early stage and discrimination of pSS patients than those with idiopathic sicca symptoms.
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