Changes in Some Urinary Variables After Potassium Citrate Therapy In Patients With Recurrent Urinary Stone Disease In Tikrit City, Iraq

Authors

  • Mohammed Mohsin Abdul-Aziz1, Nihad Nejres Hilal2, Mohanned Hussam Mohammed Saeed Alkumait3

Keywords:

Urinary calcium, Urinary magnesium, Urinary volume, Urinary pH, Potassium citrate.

Abstract

Objective: to determine the effect of oral potassium citrate (k-citrate) on urinary calcium, magnesium, volume, and pH in patients with recurrent stone disease.
Patients & Method: Interventional clinical trial study was implemented from June 2016 to February 2019 in Tikrit city, Iraq. 94 patients with recurrent urinary stone disease were enrolled in this study. Oral k-citrate therapy was given to patients in a dose of 15 meq three times daily for 2 weeks. Patients instructed for 24 hours urinary collection before and after therapy. Urinary calcium, magnesium, volume, and pH were measured before and after therapy to examine the effect of k-citrate.
Results: mean age was 38.5 (SD 17.4) years. Male patients were 64% while 36% of patients were females. Mean urinary calcium level decreased significantly after k-citrate therapy, p value < 0.001. Mean urinary volume and pH increased significantly after therapy, p value < 0.01 and < 0.05 respectively. No significant change was identified in mean urinary magnesium level after therapy, p value = 0.14. No adverse effects related to k-citrate therapy were reported by patients during study period.
Conclusion: Urinary volume and pH increased significantly in patients after potassium citrate therapy. Also k-citrate therapy significantly produced marked decrease in urinary calcium level. No change was observed in mean urinary magnesium level before and after k-citrate therapy. No adverse effects related to k-citrate therapy were reported by patients during study period.

Author Biography

Mohammed Mohsin Abdul-Aziz1, Nihad Nejres Hilal2, Mohanned Hussam Mohammed Saeed Alkumait3

1Assistant Professor of Urology, Tikrit University, College of Medicine), 2Assistant Professor of Chemical, Pathology, Tikrit University, College of Medicine, 3Assistant Professor of Urology, Tikrit University, College of Medicine

Published

2020-01-16

How to Cite

Mohammed Mohsin Abdul-Aziz1, Nihad Nejres Hilal2, Mohanned Hussam Mohammed Saeed Alkumait3. (2020). Changes in Some Urinary Variables After Potassium Citrate Therapy In Patients With Recurrent Urinary Stone Disease In Tikrit City, Iraq. Indian Journal of Forensic Medicine & Toxicology, 14(1), 299-302. Retrieved from http://medicopublication.com/index.php/ijfmt/article/view/60