Free Radicals and Oxidative Stress: The Role of Mitochondria in Aging and Mortality

Authors

  • Asima Tripathy1 , Rajat Kumar Pradhan2

DOI:

https://doi.org/10.37506/ijphrd.v11i8.10890

Keywords:

Free radicals, Antioxidant defense system, aging, mitochondria, oxyradicals

Abstract

Free radicals are important in living systems and the antioxidant defense system is required to regulate and

balance them to maintain the life of the organism. Oxygen toxicity is one of the most important reasons of

diseases and aging. The key to longer life span of an organism lies with reduction of formation of oxyradicals.

We propose that mitochondria being the site of free radical production and control during cellular respiration,

are the main organelle responsible for aging. We also discuss the possibility of upregulation of apoptosis by

the mitochondrial route by which one can indefinitely prolong the life of a cell and hence of an organism.

Author Biography

  • Asima Tripathy1 , Rajat Kumar Pradhan2

    1Post Graduate Department of Zoology and Microbiology, 2Post Graduate Department of Physics, Bhadrak

    Autonomous College (Departmentment of Higher Education, Govt. of Odisha), Bhadrak, Odisha, India

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Published

2020-08-31

How to Cite

Free Radicals and Oxidative Stress: The Role of Mitochondria in Aging and Mortality. (2020). Indian Journal of Public Health Research & Development, 11(8), 19-23. https://doi.org/10.37506/ijphrd.v11i8.10890