A Study to Find Out the Association of Vitamin D Levels with Leiomyoma Uterus
Keywords:Vitamin D; Leiomyoma uterus; Cell proliferation; Extracellular matrix production; Antifibrotic factor
Objective: To find out the the association of vitamin D levels with leiomyoma and to study its role as a risk
factor for development of leiomyoma.
Materials & Methods: Total 50 patients, belonging to age group 18-50 years, attending gynaecology OPD
of CSS Hospital, were included in this study. Those diagnosed with leiomyoma on ultrasound scan, were
labeled as case group. Control group comprised of 50 women whose pelvic ultrasound was normal and
there was no fibroid. Volume of each fibroid was measured by transvaginal sonography. The quantitative
detection of serum vitamin D levels was performed using chemi-luminescence assay. Statistical analysis was
performed using suitable tests of significance.
Results: The mean level of vitamin D in the case group was 12.9+3.09 ng/ml while in the control group
was 18.1±4.72 ng/ml (p = 0.001). Out of 50 cases, 32 (44%) cases were deficient i.e.vitamin D levels were
less than 10 ng/ml, while in controls, 15 (14%) were deficient with p value <0.001. In our study 24 cases
(48%) were vitamin D insufficient i.e. vitamin D levels between 10-20 ng/ml while 16 (32%) controls were
Conclusions: In this study low levels of vitamin D were associated with a higher risk of uterine fibroids.
So vitamin D may be a potential protective factor against the development of leiomyoma. Cohort and
Interventional studies are however pressingly needed to confirm a causal relationship and to investigate the
potential therapeutic benefits of vitamin D supplementation. Vitamin D could be a potential safe, nonsurgical
therapy for the treatment of uterine fibroids.