The Correlation between Thyroid Function Status and Bone Mineral Density among Postmenopausal Women
Keywords:Thyroid Function , Bone Mineral Density, Postmenopausal Women
Background: the relationship between thyroid function and bone has been empirically known for ages. Loss
of bone with aging in universal phenomenon effecting both men and women and associated with reduces
bone strength and increased fracture risk. The link between bone mineral dignity, bone quality and the risk
of fracture with thyroid hormones in normal postmenopausal women suggest a role for these hormones, even
with the range of normal thyroid in these diseases.
Objective: To investigate the relation between thyroid function status and bone mineral density among
Study design: A cross-sectional study
Setting: Department of Obstetrics and Gynecology of Al-Yarmouk teaching hospital in cooperation with
Lab of National Institute of Diabetic Center and Dexa unit.
Patients and methods: The study has included one hundred postmenopausal women with age between
(45-70) years old, who attended outpatient clinic or DEXA unit. Inform consent had been taken from all
participants about nature of study. Demographic information and medical history were collected using a
detailed questionnaire. After the collection of data, blood samples had been taken for evaluation of thyroid
function by measuring the serum level of THS, FT3 and FT4. Dual energy X ray (DEXA) was used to assess
bone mineral density.
Results: The mean age of the study group was 58.8 years and the mean of BMI was (33.2 ± 5.35). The
highest proportion of study patients diagnosed as Euthyroid was (63%).Proportion of osteoporosis diagnosed
in spine was higher than osteoporosis diagnosed in left femur (35% versus 4%), while osteopenia was higher
in left femur than spine (49% versus 45%).The highest proportion of study patients with hypothyroidism and
those with Euthyroid was not osteoporotic (60% and 76.2% respectively), while those with hyperthyroidism,
more than half of them were osteoporotic (55.6%) with a statistically significant association (P=0.013)
between Thyroid function and bone mineral density levels.
Conclusion: There is a significant direct correlation between thyroid function and bone mineral density
among postmenopausal women, but further investigations are needed to recognized all factors effecting this
relationship with using wide sample size.