A Study to Evaluate Subclinical Muscle Strength Decrease and Quality of Life among Diabetes Individuals
Background : Diabetes mellitus is a metabolic disorder of multiple aetiologies characterized by chronic
hyperglycemia resulting from defects in insulin secretion or insulin action. Muscle strength is influenced
by insulin resistance, through higher plasma levels, and lipid content in the muscle, therefore it could be a
marker for impaired skeletal muscle. These structural and functional changes in the skeletal muscle caused
by defective insulin action could be associated with muscle weakness and reduced endurance capacity.
This study evaluates the subclinical changes in muscle strength in diabetes and its functional performance
comparing with age-matched healthy subjects.
Methods: This observational study totally includes 80 male and female individuals, 40 of type 2 DM and
another 40 of age matched healthy individuals without any difficulty in Activities of daily living were
recruited above 60 years of age, and assessed with HHD and functional measure (FTSTS) and quality of life
measure (SF 36) used.
Results: Independent sample T test and Pearson correlation coefficient was used to analyze the difference
and correlate among lower extremity muscle strength, FTSTS, and SF 36 in diabetic and healthy individuals;
the data obtained were statistically significant, except SF 36 emotional limitation and physical limitation
factor were non-significant. Pearson’s coefficient found to have weak negative correlation in SF 36 and
Conclusion: Type 2 diabetes mellitus has correlated with reduction in muscle strength particularly in lower
limb which remains subtle and unidentified as the disease progresses the muscle weakness may become
progressive and lead to immobilit