Relationship of Obesity Recurrence Events in Triple Negative Breast Cancer Patients in Dr. Soetomo General Hospital Surabaya
Keywords:triple negative breast cancer, recurrence, obesity, cancer breast.
Background : Breast cancer is one of most major cause of death in women. One of the forms of breast
cancer that has poor prognosis is triple negative breast cancer (TNBC). TNBC occurs in 10-20% of breast
cancer, with high number of relapse/recurrence and metastasis. In some earlier research, it was found that the
number of TNBC was higher in patients with obesity. Therefore, obesity is associated with poor prognosis
in patients with breast cancer. This research wants to study the relationship of obesity with recurrence in
TNBC patients .
Method: This research is a prospective cohort research in patients with triple negative breast cancer.
Research was carried out by recording patients with TNBC and measurement of the degree of obesity by
calculating the body mass index (BMI). Patients was followed-up for 6 months after surgery to monitor if
there is any recurrence.
Results: In this research, it was obtained a total of patients of 58, 33 people (56.9%) with normal BMI and
25 people (43.1%) with obesity. From the terms of recurrence, it was obtained 30 people (51.7%) did not
experience recurrence and 28 people (48.3%) experienced a recurrence. Statistical tests proved that there
is significant relationship between obesity with the incidence of recurrence (p = 0.002) with an odds ratio
(OR) of 6.29.
Conclusion: Increased BMI increase the incidence of recurrence cases in patients with Triple Negative