Relationship of Albumin-CRP Ratio on Neoadjuvan Clinical Response of Caf Regiment Chemotherapy in Women with Locally Advance Breast Cancer in Rsud Dr. Soetomo
Keywords:locally advanced breast cancer, CRP, albumin, CRP/Albumin ratio, response to chemotherapy, breast cancer
Background : Breast cancer is the most common cancer in women and is the highest cause of death. As
many as 2.1 million women in the world suffer from breast cancer each year. Data in Dr. Soetomo Hospital
show patient cancer breast came with a case of locally advanced breast cancer as much as 47% and 52% of
the cases do not respond well to neoadjuvant chemotherapy. The inflammatory state and nutritional status of
the patient play a role in the therapeutic success of the patient. The presence of inflammation and the status
of the nutrients are poorly related to the response of clinically against chemotherapy are low. The state of
inflammation and status of nutrition it can be seen from the ratio between CRP with albumin.
Method: The research was a prospective cohort design, on patients with locally advanced breast cancer.
Patients performed the examination levels of albumin and CRP before the chemotherapy is given and carried
out the measurement of the mass of the tumor with a physical examination. Then the patient underwent
neoadjuvant chemotherapy with the CAF regimen for 3 cycles and was examined for CRP, albumin, and
tumor size again. Then evaluated for response to therapy.
Results: In this study, a total of 35 patients were obtained with 12 people (34.3%) with a low CRP / Albumin
ratio and 23 people (65.7%) with a high CRP / Albumin ratio. From the clinical response found 0 people
(0%) with progressive disease, 7 people (20%) with stable disease, 23 people (65.7%) with partial response
and 5 people (14.3%) with complete response. Statistical test results showed that there was a significant
relationship between CRP / Albumin ratio with chemotherapy response (p = 0.004).
Conclusion: It was obtained a significant relationship between the increased ratio of CRP / Albumin with
a decrease in response to neoadjuvant chemotherapy of CAF in patients with Locally Advanced Breast