Comparison of Bone Turnover Markers on Osteoporosis in Pre and Postmenopausal Women

Authors

  • Raja Marimuthu1 , PrabhakarReddy.E2

DOI:

https://doi.org/10.37506/ijphrd.v11i11.11365

Keywords:

Osteoporosis,Bone turnover, Alkaline phosphatase, Hydroxyproline, Osteopenia

Abstract

Osteoporosis, a major public health problem, is becoming increasingly prevalent with the aging of the
world population. Rapid bone loss occurs in postmenopausal women due to hormonal factors which
lead to increased risk of fractures. Biochemical markers of bone metabolism are used to assess skeletal
turnover. Bone formation markers (Total Calcium, Ionised calcium,Alkaline phosphatase), and bone
resorption markers (Urinary Hydroxyproline) were analysed in pre and post menopausal women. A crosssectional study of 200pre- and post menopausal women was carried out at Sree Balaji Medical College
and Hospital,chennai. Bone formation markers (Total Calcium, Ionised calcium, Alkaline phosphatase),
and bone resorption markers (Urinary Hydroxyproline) were analysed in pre and post menopausal women.
Bone formation markers, Total and Ionised calcium were significantly decreased (p<0.001) and Alkaline
phosphatase was significantly increased (p<0.001) in postmenopausal women compared to premenopausal
women. Bone resorption markers, Urinary hydroxyproline excretion was significantly increased (p<0.001)
in postmenopausal women. The results from this study suggests that simple, easy, common biochemical
markers such as age, years after menopause,urinary hydroxyproline, total serum ALP, total serum calcium
and ionized calcium could be used as indicators of increased bone turnover, to enable early intervention so
as to minimize fracture due to osteoporotic changes.

Author Biography

Raja Marimuthu1 , PrabhakarReddy.E2

1
Associate Professor of Orthopaedics, Sree Balaji Medical college and Hospital, Chrompet, Chennai, 2Professor of
of Biochemistry and Central Laboratory Head, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry- ,
India

Published

2020-10-21

How to Cite

Raja Marimuthu1 , PrabhakarReddy.E2. (2020). Comparison of Bone Turnover Markers on Osteoporosis in Pre and Postmenopausal Women. Indian Journal of Public Health Research & Development, 11(11), 154-162. https://doi.org/10.37506/ijphrd.v11i11.11365