A Study of Platelet Indices in Patients with Metabolic Syndrome and Type 2 Diabetes Mellitus
Keywords:Platelets, Metabolic Syndrome, Type 2 Diabetes Mellitus, Nitric Oxide, Hematological parameters, Triglycerides.
Altered platelets have been reported in patients with diabetes mellitus and MS has been considered as
a ‘prothrombotic state’ with enhanced platelet reactivity. They have been associated with increased risk
of vascular complications in these patients. Platelet indices correlate with functional status of platelets
and is an emerging risk factor of vascular complications in diabetes and MS. The study was undertaken
to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus and MS. Results
of our study may lay a foundation for a discovery of new approaches for prevention and treatment of
cardiovascular complications in MetS and DMT2 in early stages of metabolic disorders in patients. MetS is
a proinflammatory and prothrombotic state, characterized by alteration of platelet indices. Plateletcrit was
shown to be a significant biomarker along with other parameters, including waist circumference,SBP, and
serum triglyceride levels. Platelet activation causes high risk of cardiovascular complications in MetS. T2
DM is associated with the changes in the intra cellular signaling systems regulating platelet functions.