Evaluation of Hepatotoxicity of Two Famous Antiepileptic Drugs Depakine® and / or Epanutin® in Male Albino Mice Mus Musculus: Integrated Biochemical and Histological Studies
Keywords:aminotransferase, epilepsy, liver, phenytoin sodium, valproate.
Background: depakine and epanutin introduce useful tools in wide range of clinical issues. Liver is the local
position for their metabolism and is susceptible for their influences.
Methods: forty-two male albino mice were divided into seven groups. control group injected with NaCl
(0.9%) 1ml/kg, group 2 injected with depakine 25mg/kg/day, group 3 injected with depakine 50mg/kg/day,
group 4 injected with epanutin 3mg/kg/day, group 5 injected with epanutin 6mg/kg/day, group 6 injected
with (depakine 25 + epanutin 3) mg/kg/day and group 7 injected with (depakine 50 + epanutin 6) mg/kg/
day. All animals were injected intraperitoneally, were fasted 12hours after last injection, were sacrificed via
cervical dislocation and specimens were collected after one and two weeks for each dose.
Conclusions: human therapeutic doses range of depakine and/or epanutin produced elevation in the mean of
liver aminotransferases enzymes levels in serum without dose or time depend and generate variable degrees
of hepatotoxicity in mice according to dose and depend on time.