Evaluation of Hepatotoxicity of Two Famous Antiepileptic Drugs Depakine® and / or Epanutin® in Male Albino Mice Mus Musculus: Integrated Biochemical and Histological Studies

Authors

  • Nagla Zaky Ibrahim El -Alfy1 , Amany Ibrahim Alqosaibi2 , Mahmoud Fathy Mahmoud3 , Ayman Mohammad Abdullah4

DOI:

https://doi.org/10.37506/ijphrd.v11i11.11378

Keywords:

aminotransferase, epilepsy, liver, phenytoin sodium, valproate.

Abstract

Background: depakine and epanutin introduce useful tools in wide range of clinical issues. Liver is the local
position for their metabolism and is susceptible for their influences.
Methods: forty-two male albino mice were divided into seven groups. control group injected with NaCl
(0.9%) 1ml/kg, group 2 injected with depakine 25mg/kg/day, group 3 injected with depakine 50mg/kg/day,
group 4 injected with epanutin 3mg/kg/day, group 5 injected with epanutin 6mg/kg/day, group 6 injected
with (depakine 25 + epanutin 3) mg/kg/day and group 7 injected with (depakine 50 + epanutin 6) mg/kg/
day. All animals were injected intraperitoneally, were fasted 12hours after last injection, were sacrificed via
cervical dislocation and specimens were collected after one and two weeks for each dose.
Conclusions: human therapeutic doses range of depakine and/or epanutin produced elevation in the mean of
liver aminotransferases enzymes levels in serum without dose or time depend and generate variable degrees
of hepatotoxicity in mice according to dose and depend on time.

Author Biography

Nagla Zaky Ibrahim El -Alfy1 , Amany Ibrahim Alqosaibi2 , Mahmoud Fathy Mahmoud3 , Ayman Mohammad Abdullah4

1 Professor of Cytogenetics, 2Professor of Cytology and Histology, 3PhD Researcher, Department of Biological and
Geological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt, 4
Assistant Professor of Molecular
genetics, Department of Biology, College of Science, University of Imam Abdulrahman bin Faisal, Dammam, Saudi
Arabia

Published

2020-10-21

How to Cite

Nagla Zaky Ibrahim El -Alfy1 , Amany Ibrahim Alqosaibi2 , Mahmoud Fathy Mahmoud3 , Ayman Mohammad Abdullah4. (2020). Evaluation of Hepatotoxicity of Two Famous Antiepileptic Drugs Depakine® and / or Epanutin® in Male Albino Mice Mus Musculus: Integrated Biochemical and Histological Studies. Indian Journal of Public Health Research & Development, 11(11), 235-241. https://doi.org/10.37506/ijphrd.v11i11.11378