Iron profile and Hepcidin Associated with Oxidative Stress and Metabolic Disturbances in Pregnancy
Keywords:hepcidin, iron, oxidative stress, pregnancy,
Background: A common problem during pregnancy is anemia and to reduce its prevalence the WHO and
national guidelines recommend a prescription of 30 to 60 mg of iron/day. The aim of this study was to
evaluate the association of iron profile, hepcidin and oxidative stress in pregnant women prescribed with
iron as a probable cause of metabolic disorders.
Method: In this cohort study two groups were followed: A) women with low-risk pregnancy (WLRP), B)
women with high-risk pregnancy (WHRP): women with metabolic disorders (dyslipidemias, GDM and high
blood pressure). Oxidative stress enzymes, iron profile and hepcidin were measured in the second and third
Results: There were significant differences in hepcidin levels between WLRP and WHRP in 2nd (3.6 ± 4.2
vs 4.69 ± 3.23 P=0.005) and 3rd trimester (3.65 ± 3.44 vs 6.84 ± 5.14 P=0.02). The serum iron concentration
had a negative relationship with catalase (-0.599; P=0.04) and a positive relationship with glutathione
peroxidase (0.729; P=0.007).
Conclusion: The iron serum levels increase could induce oxidative damage in pregnancy. Increased hepcidin
is a useful biomarker for determining iron availability in pregnancy and its association with antioxidant