Iron profile and Hepcidin Associated with Oxidative Stress and Metabolic Disturbances in Pregnancy

Authors

  • Karla Mariana Ortega López1, Araceli Amaya Chávez2 , Patricia Vieyra Reyes3 , Hugo Mendieta Zerón4

DOI:

https://doi.org/10.37506/ijphrd.v11i11.11390

Keywords:

hepcidin, iron, oxidative stress, pregnancy,

Abstract

Background: A common problem during pregnancy is anemia and to reduce its prevalence the WHO and
national guidelines recommend a prescription of 30 to 60 mg of iron/day. The aim of this study was to
evaluate the association of iron profile, hepcidin and oxidative stress in pregnant women prescribed with
iron as a probable cause of metabolic disorders.
Method: In this cohort study two groups were followed: A) women with low-risk pregnancy (WLRP), B)
women with high-risk pregnancy (WHRP): women with metabolic disorders (dyslipidemias, GDM and high
blood pressure). Oxidative stress enzymes, iron profile and hepcidin were measured in the second and third
trimesters.
Results: There were significant differences in hepcidin levels between WLRP and WHRP in 2nd (3.6 ± 4.2
vs 4.69 ± 3.23 P=0.005) and 3rd trimester (3.65 ± 3.44 vs 6.84 ± 5.14 P=0.02). The serum iron concentration
had a negative relationship with catalase (-0.599; P=0.04) and a positive relationship with glutathione
peroxidase (0.729; P=0.007).
Conclusion: The iron serum levels increase could induce oxidative damage in pregnancy. Increased hepcidin
is a useful biomarker for determining iron availability in pregnancy and its association with antioxidant
systems.

Author Biography

Karla Mariana Ortega López1, Araceli Amaya Chávez2 , Patricia Vieyra Reyes3 , Hugo Mendieta Zerón4

Research Scholar, Faculty of Chemistry, Autonomous University of the State of México (UAEMéx), 2. Professor,
Faculty of Chemistry, Autonomous University of the State of México (UAEMéx), 3
Professor, Faculty of Faculty of
Medicine, Autonomous University of the State of México (UAEMéx), 4Professor, Faculty of Faculty of Medicine,
Autonomous University of the State of México (UAEMéx) and “Mónica Pretelini Sáenz” Maternal-Perinatal
Hospital (HMPMPS)

Published

2020-10-21

How to Cite

Karla Mariana Ortega López1, Araceli Amaya Chávez2 , Patricia Vieyra Reyes3 , Hugo Mendieta Zerón4. (2020). Iron profile and Hepcidin Associated with Oxidative Stress and Metabolic Disturbances in Pregnancy. Indian Journal of Public Health Research & Development, 11(11), 313-321. https://doi.org/10.37506/ijphrd.v11i11.11390