Prevalence and Profile of Device Associated Infection in Precisely Tribal Sickle Cell Disease children above 10 years of Age Admitted to ICU of a Tertiary Care Hospital of Tribal Area
Keywords:Sickle cell disease (SCD), Device Associated infections (DAI), Central line-associated bloodstream infections (CLABSI), Ventilator-associated pneumonia (VAP), Catheter-associated urinary tract infections (CAUTI).
Background:Sickle cell disease (SCD) children are more susceptible to bacterial infection due to
multifactorial causewith poorimmunization status in tribal area.Device associated infections (DAIs) , due to
extensive use of invasive devices in intensive care units , further increases morbidity and mortality in these
patients . In the present study ,our aim is to define , the total burden and profile of DAI as presentation ,
spectrum of bacterial isolate and susceptibility in SCD children, in specific to, ICU of a tertiary care Hospital in
Tribal area. Methodology:This prospective study was conducted overDevice Associated infections (DAIs)
in Sickle cell disease (SCD) tribal children, having an inserted indwelling device, in the ICU of atertiary care
hospital.Demographic ,clinical and date of device insertion data were recorded . Depending on the type
of specimen, samples were cultured and analyzed .Antimicrobial susceptibility testing was performed on
different isolates. Result: Out of 31 exposed SCD children to indwelling devices,the confirmed DAI cases
were, 1 central line-associated bloodstream infections (CLABSI), 1 ventilator-associated pneumonia (VAP),
and 3 catheter-associated urinary tract infections (CAUTI ). The overall DAI rate was 16.1% with 29.7 per
1000 device days . The Organism causing infection were Gram-negative in 3(60% ) cases , Gram-positive
in 2 (40% ), and as mixed infection with fungal organisms in 2( 40%) cases. Most isolates were susceptible
to Co-Trimoxazole , Ceftriaxone and Gentamycin . CONS and Klebsiella were showing multidrugresistant
to more antibiotics tested.Conclusion:Since,In view of high DAIrate in Sickle cell Disease Tribal children
in the ICU of tribal area,the preventive strategies should be plannednot only to improve immunity but also
reduce morbidity ,mortality , to ensure a good quality health care in them.
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