Platelet To Lymphocyte Ratio Relationship With Neoadjuvant Chemotherapy Of Caf Regiment Response In Locally Advanced Breast Cancer Patients

Authors

  • Ali Sibra Mulluzi1 ; Hantoro Ishardyanto2 ; Iskandar Ali2 ; Hartono Kahar3

DOI:

https://doi.org/10.37506/ijphrd.v12i1.13853

Keywords:

locally advanced breast cancer, platelet to lymphocyte ratio, chemotherapy, neoadjuvant

Abstract

Background: Chemotherapy in breast cancer can be given as neoadjuvant or adjuvant therapy. The response
to neoadjuvant chemotherapy is very important in cancer management, especially in locally advanced breast
cancer, therefore predictive factors which can predict chemotherapy response are very important. Platelet to
lymphocyte ratio is a simple examination, which has been used as predictive factor in various cancer. This
study will be focussing on locally advanced breast cancer.
Method: The study design is prospective cohort study. The research subjects examined the levels of platelets
and lymphocytes in the blood before chemotherapy. Blood was drawn 1 day before the first chemotherapy
session. Then the patient’s clinical response was assessed after 3 cycles of chemotherapy. Each cycle is
carried out at intervals of 3 weeks. Furthermore, the platelet to lymphocyte ratio and chemotherapy response
will be assessed and analyzed.
Results: The research subjects consisted of 35 women. In this study, it was found that the mean value of
platelets was 388,228 ± 141.5 g / dl, with a maximum value of 834,000 g / dl and a minimum of 206,000 g /
dl. In the lymphocyte, the mean results were 2,025 ± 759 mg / l with a maximum lymphocyte value of 4,210
g / dl and a minimum of 800 g / dl. From the results of this study, the mean platelet / lymphocyte ratio was
232.9 ± 212.9 uL with a minimum value of 80.51 uL and a maximum of 1052 uL. In this study, it was found
that most of the patients experienced a partial response in 23 patients (65.7%) and it was found that there was
a significant relationship between the platelet / lymphocyte ratio and the clinical response of local advanced
breast cancer patients with p value = 0.028 (p. <0.05)
Conclusion: There is significant relationship between the platelet / lymphocyte ratio and the clinical
response of chemotherapy in locally advanced breast cancer patients. The higher the platelet to lymphocyte
ratio, worse chemotherapy response is expected.

Author Biography

Ali Sibra Mulluzi1 ; Hantoro Ishardyanto2 ; Iskandar Ali2 ; Hartono Kahar3

1
Resident of Surgery, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya,
2Staff of the Department of Surgery, Oncology Division, Faculty of Medicine Universitas Airlangga /Dr. Soetomo
General Hospital Surabaya, 3Staff of the Department of Clinical Pathology, Faculty of Medicine Universitas
Airlangga /Dr. Soetomo General Hospital Surabaya

Published

2021-01-07

How to Cite

Ali Sibra Mulluzi1 ; Hantoro Ishardyanto2 ; Iskandar Ali2 ; Hartono Kahar3. (2021). Platelet To Lymphocyte Ratio Relationship With Neoadjuvant Chemotherapy Of Caf Regiment Response In Locally Advanced Breast Cancer Patients. Indian Journal of Public Health Research & Development, 12(1), 223-229. https://doi.org/10.37506/ijphrd.v12i1.13853