Immunohistochemical assessment of MMR Proteins, BRAF Mutation and Beta-Catenin in Colorectal Carcinoma in Egypt

Authors

  • Marwa. A. Ahmed1 , Mohammed. A. Nouh2 , Hoda. Ismael2, Salim. E. Salem3 , Ahmed. Rabie4 , Asmaa. I. Salama2

DOI:

https://doi.org/10.37506/ijphrd.v12i1.13869

Keywords:

CRC, dMMR, BRAF mutation, Beta-Catenin, immunohistochemistry, prognosis

Abstract

We conduct this study to investigate the prevalence of dMMR, BRAFV600E mutation and nuclear BetaCatenin among Egyptian CRC cases and correlate results with clinico-pathological parameters and survival.
Immunohistochemical assessment of MMR, BRAF and Beta-Catenin was carried out on 83 CRC cases.
dMMR, BRAFV600E mutation and nuclear Beta-Catenin expression were identified in (48.2%), (20.5%)
and(4.8%)of cases. For MMR and BRAF, none of the clinicopathologic parameters were significantly
correlated with their status. Despite that the 5-year PFS was slightly better in dMMR tumors than pMMR
tumors; yet, the statistical difference could not be verified. BRAF mutation had no prognostic impact on
OS and PFS. The smaller number of Beta-Catenin positive tumors precluded the drawing of definitive
conclusion concerning its prognostic role.

Author Biography

Marwa. A. Ahmed1 , Mohammed. A. Nouh2 , Hoda. Ismael2, Salim. E. Salem3 , Ahmed. Rabie4 , Asmaa. I. Salama2

1Assistant lecturer, Department of Pathology, National Cancer Institute, Cairo University. 2Professor, Department
of Pathology, National Cancer Institute, Cairo University, 3Professor, Department of Medical Oncology, National
Cancer Institute, Cairo University, 4Lecturer, Department of pathology, Al-Azhar University

Published

2021-01-07

How to Cite

Marwa. A. Ahmed1 , Mohammed. A. Nouh2 , Hoda. Ismael2, Salim. E. Salem3 , Ahmed. Rabie4 , Asmaa. I. Salama2. (2021). Immunohistochemical assessment of MMR Proteins, BRAF Mutation and Beta-Catenin in Colorectal Carcinoma in Egypt. Indian Journal of Public Health Research & Development, 12(1), 324-331. https://doi.org/10.37506/ijphrd.v12i1.13869