Relationship between Procalcitonin and C-Reactive Protein on Pelod Score in Pediatric Surgery Sepsis Patients at Dr Soetomo General Hospital Surabaya

Authors

  • Putu Andika Rama Wismawan1 ; Ariandi Setiawan2 ; Jusak Nugraha3

DOI:

https://doi.org/10.37506/ijphrd.v12i1.13875

Keywords:

PELOD, sepsis, CRP, procalcitonin

Abstract

The incidence of sepsis in the world was estimated around 1.8 million cases / year , whereas 25-38% of
them requiring treatment in intensive care unit , with mortality of 1,400 cases / day . In Indonesia, child’s
mortality rate due to sepsis is still very high, around 50% -70%, and if accompanied with septic shock and
multiple organs dysfunction, the rate is increased (80%) . One of the scoring system that can describe the
severity degree of multiple organs dysfunction in children is PELOD (Pediatric Logistic Organ Dysfunction)
score. But this assessment is time consuming, because many parameters that have to be calculated. One of
the ways to shorten the time is by using diagnostic markers such as procalcitonin (PCT) and C-Reactive
Protein (CRP).
Method: The research is a study of analytic observational to determine the relationship between PELOD
score with a value of procalcitonin and CRP in patients of children with sepsis and determine the cutoff point
of procalcitonin and CRP can be associated with incidence of septic shock. Research carried out for three
months started in January 2020 until April 2020. Patients who meet the criteria for inclusion and exclusion
requested approval. Laboratory blood tests were done from day 1-3 of the sepsis.
Results: In the study it was obtained the result that the age of majority is in the category of 5-10 years that
as many as 11 patients (36.7%). In the category of the type of sex the most are men - men that 19 patients
(63.3%) and patients mostly great suffering sepsis that 23 patients (76.7%). Analysis between CRP with
PELOD Score by using the chi-square test , the obtained results that there is a relationship that significant
between CRP with PELOD Sc ore on a day to 1-3 with a value of p value of each 0,001 ( p < 0,05) ; 0.002
( p < 0.05) ; 0.004 ( p < 0.05), which means that there is significant relationship between CRP with PELOD
Score . Analysis between PCT with PELOD Score by using the chi-square test , the obtained results that
there is a relationship that significant between PCT with PELOD Score on a day to 1-3 with a value of
p value respectively 0.005 ( p < 0,05) ; 0.001 ( p> 0.05) ; 0.016 ( p> 0.05), which means that there is a
relationship which is significantly meaningful between PCT with PELOD Score. In research it obtained the
value of the boundary between the groups of patients with sepsis with shock, sepsis is Pelod score value of
29 is the boundary between groups of sepsis and shock, sepsis, CRP value of 88 is the boundary between
groups of sepsis and shock, sepsis, PCT value 9 is the boundary between groups of sepsis and shock sepsis .
Conclusion: There is a significant relationship between the PCT with PELOD Score and significant
relationship between the CRP with PELOD Score.

Author Biography

Putu Andika Rama Wismawan1 ; Ariandi Setiawan2 ; Jusak Nugraha3

1
Resident of Surgery, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital Surabaya,
2Staff of the Department of Surgery, Pediatric Surgery Division, Faculty of Medicine Universitas Airlangga /
Dr. Soetomo General Hospital Surabaya, 3Staff of the Department of Clinical Pathology, Faculty of Medicine
Universitas Airlangga /Dr. Soetomo General Hospital Surabaya

Published

2021-01-07

How to Cite

Putu Andika Rama Wismawan1 ; Ariandi Setiawan2 ; Jusak Nugraha3. (2021). Relationship between Procalcitonin and C-Reactive Protein on Pelod Score in Pediatric Surgery Sepsis Patients at Dr Soetomo General Hospital Surabaya. Indian Journal of Public Health Research & Development, 12(1), 370-378. https://doi.org/10.37506/ijphrd.v12i1.13875