Ameliorative Effect of Taraxacum officinale Leaves on Hormonal Status of Hyperglycemic Rats

Authors

  • Reham, A. Mostafa
  • Doaa R. Negm
  • Eslam A. Header
  • Wafaa F. Abusudah
  • Wedad F. Azhar

DOI:

https://doi.org/10.37506/ijphrd.v12i2.14158

Keywords:

Sex hormone - Dandelion (Taraxacum official) - Diabetes-Glucose - Rats.

Abstract

Acute or chronic side effects of hyperglycemia may affect all systems and organs, such as sexual glands.
Approximately 90 percent of diabetic patients suffer from sexual dysfunction, including libido and fertility.
This study is designed to investigate the effect of diabetes on the sex hormones levels ad to evaluate the
ameliorative effect of dandelion leaves powder (DLP) on diabetes-induced changes of gonadal hormones
and glucose serum levels in male rats. Experimental diabetes mellitus was induced by subcutaneous injection
with 65mg streptozotocin STZ/kg body weight. DLP was given in pelleted food at ratio of 5% for 28 days.
DLP was effective in lowering Follicle-stimulating hormone (FSH) serum level in dandelion-treated rats
compared to controls in diabetic group. DLP was also able to reverse the progesterone lowering effect of
diabetes. In all of the classes, the estrogen level did not show any noticeable difference. It is suggested that
DLP can have a regulatory effect in male rats on diabetes-induced changes in gonadal hormone levels,
especially progesterone. Our research has shown that long-term administration of DLP in the diabetes
experimental model could be used as a good candidate for reproductive hormone deficiency therapy

Author Biographies

Reham, A. Mostafa

Assistant Professor in Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura
University, Makkah, Kingdom of Saudi Arabia

Doaa R. Negm

Assistant Professor in Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura
University, Makkah, Kingdom of Saudi Arabia

Eslam A. Header

Professor in Department of Clinical Nutrition, Faculty of Applied
Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia & Department of Nutrition and
Food Science, Faculty of Home Economics, Menofia University, Egypt

Wafaa F. Abusudah

Assistant Professor in Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura
University, Makkah, Kingdom of Saudi Arabia

Wedad F. Azhar

Assistant Professor in Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura
University, Makkah, Kingdom of Saudi Arabia

Published

2021-03-01

How to Cite

Reham, A. Mostafa, Doaa R. Negm, Eslam A. Header, Wafaa F. Abusudah, & Wedad F. Azhar. (2021). Ameliorative Effect of Taraxacum officinale Leaves on Hormonal Status of Hyperglycemic Rats. Indian Journal of Public Health Research & Development, 12(2), 358-364. https://doi.org/10.37506/ijphrd.v12i2.14158