Predictive Factors Associated with Ovarian Hyperstimulation Syndrome in Indonesian Women Undergoing IVF

Authors

  • Valerie Afiyah Marzuki
  • Zakiyatuh Faizah
  • R. Haryanto Aswin
  • Ashon Sa’adi

DOI:

https://doi.org/10.37506/ijphrd.v12i2.14171

Keywords:

OHSS, IVF, prediction, prevention, risk factors.

Abstract

Background: In line with the increasing practice of in-vitro fertilization, it is crucial to pay attention onits
complications. The most common iatrogenic complication of assisted reproductive technologies (ART)
is ovarian hyperstimulation syndrome (OHSS). Several characteristics are useful in identifying high-risk
patients in order to prevent OHSS.
Method: This study analysed characteristics of age, body mass index (BMI), antral follicle count (AFC),
estradiol levels, and the number of oocytes between two unpaired groups of 20 women with OHSS and 19
women, who did not experience OHSS.
Results: The characteristics of AFC (p = 0.012), estradiol levels (p <0.001), and the number of oocytes (p
<0.001) showed were significantly different between the two groups. Women with higher AFC were more
likely to have OHSS, with OR of 3.33 (95% CI 0.77–14.31). Additionally, women with higher levels of
estradiol and number of oocytes were also more likely to have OHSS, OR 76.5 (95% CI 9.66–605.67) and
81 (95% CI 4.2–1561.6), respectively. Other patient’s characteristics did not differ significantly (p> 0.05).
Conclusions: Women with AFC above ten follicles, estradiol levels above 3000 pg/ml, and oocytes count
of more than 12 were more likely to develop OHSS.

Author Biographies

Valerie Afiyah Marzuki

Final Year Student, Faculty of Medicine, Universitas Airlangga

Zakiyatuh Faizah

Lecturer, Department of Biomedical Science,
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

R. Haryanto Aswin

Lecturer, Department of Biomedical Science,
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Ashon Sa’adi

Lecturer, Department of Obstetrics and
Gynecology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia

Published

2021-03-01

How to Cite

Valerie Afiyah Marzuki, Zakiyatuh Faizah, R. Haryanto Aswin, & Ashon Sa’adi. (2021). Predictive Factors Associated with Ovarian Hyperstimulation Syndrome in Indonesian Women Undergoing IVF. Indian Journal of Public Health Research & Development, 12(2), 432-437. https://doi.org/10.37506/ijphrd.v12i2.14171