A Chronic Toxicity Study of Oral Administration of  Collagen-?® Supplement using Pregnant Rabbits

Authors

Since collagen derived products are highly used in food supplements due to its bioactive properties by

influencing cellular and tissue health, flexibility with high effect of repairing and adaptation. It is necessary

to carry out safety requirement of an oral chronic toxicity assessment. This study investigated the adverse

effect of long term oral administration of collagen-® in pregnant rabbits. We have conducted a thirty

days randomized controlled trial in pregnant rabbits. Rabbits were randomized into two groups; Group 1

(control group) were administrated with 1 ml of normal saline PO, SID while Group 2 (collagen-? group)

were administered with 1 ml of collagen-?® PO, SID for one month. Bodyweight gain, viscera weight

and histopathological evaluation of the individual rabbit were recorded. The results revealed that the body

weight gain and visceral tissues weight in the collagen-? group were significantly lower than the control

group. Moreover, various histopathological changes were recorded in heart, lungs, liver and kidneys of the

collagen-? group when compared with the non-significant changes that noticed in the control group. Under

the conditions of the current study, a high risk of chronic toxic effect was observed in pregnant rabbits

inoculated with 1 ml of oral dose of collagen alpha supplement. This result suggests that the adverse effect

of collagen derived supplements is overbalancing the benefits.

Alia M. Kudayer1, Nawras A. Alwan2 , Alaa A. Sawad1

1 Department of Anatomy and histological, College of Veterinary Medicine, University of Basrah, 2Department of

Physiology, Pharmacology and Biochemistry College of Veterinary Medicine, University of Basrah.