Evaluation of Oxidative Stress and Antioxidants in Iraqi Patients with Hydatid Disease
Keywords:Hydatid disease, Echinococcus granulosus, Antioxidant, Oxidative stress.
Antioxidants and oxidative stress status are clinically important in the detection of many diseases. In order
to estimate the role of oxidative stress in hydatid disease pathogenesis, the antioxidant levels and oxidative
stress status were examined in the patients of hydatid cysts. Thirty patients having active hydatid cyst of
Echinococcus granulosus, previously diagnosed by X-ray, were adopted as patients’ group. Additionally, 25
healthy individuals who did not have hydatid infection or any other parasitic infection constituted the control
group. Antioxidant status and oxidative stress levels were determined using biochemical tests including
plasma Malondialdehyde (MDA) level, and erythrocyte Catalase (CAT), Glutathione Peroxidase (GSH
Px), Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST) activity, in addition to erythrocyte
Glutathione concentration GSH-conc. The statistical evaluation of plasma MDA levels showed significantly
higher levels in hydatid patients than in healthy controls, while erythrocyte SOD, GSH-Px, CAT, GST and
GSH levels were significantly declined in hydatid patients compared to the control which can be used as
diagnostic markers in the laboratory diagnosis of the disease. To conclude, hydatid patients show elevated
oxidative stress status, and therefore, the antioxidant therapy should be considered in addition to the routine
medicines in this group of patients.
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