Correlation between High Sensitivity-Crp Level and Executive Function Disorders in Elderly Patients

Abstract

Background: C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high

sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the

frontal-subcortical circuit.

Objective: To determine the correlation between high serum concentration of hs-CRP and executive function

disorder in elderly patients.

Method: Thirty six elderly patients was examined by using a case control study. The subjects were enrolled

from the out-patient at Neurology Departement Dr. Soetomo General Hospital, Surabaya, Indonesia. The

time period was 4 months (April to July 2015). Executive function was measured with the Trail Making

Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP

concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis.

Results: Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects

were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%)

subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated

with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0,538-58,860).

Conclusion: These data suggested that high levels of hs-CRP was not associated with executive function in

elderly patients.