Two-Years Corneal Collagen Cross-Linking Outcomes in Patients with Keratoconus


  • Mitra Zamani1 , Asghar Heidarian2 , Mohammad Sadegh Mirdehghan3



Collagen cross-linking, Keratoconus, Ultraviolet, Riboflavin


Aims: This study aimed to report refractive, topographic, and tomographic outcomes of 2-years corneal

collagen cross-linking in patients with progressive keratoconus.

Materials and Method: This prospective study was conducted on76 eyes of 40 patients with progressive

keratoconus and a corneal thickness of at least 400?m. After the baseline examination, cross-linking was

performed using riboflavin 0.1% and ultraviolet irradiation (370 nm, 3 mW/cm2) for 30 min. Uncorrected

visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refraction spherical

equivalent (MRSE), cylinder, keratometric readings, and corneal thickness were evaluated at baseline, 6,

12, and 24 months after corneal collagen cross-linking.

Results: Results showed that at a 24-month follow-up, mean BSCVA, and UCVA had significant

improvements. Changes in MRSE and cylinder were not significant during the two years of follow-up.

At a 2-years follow-up, the mean values of minimum keratometry, maximum keratometry, and average

keratometry decreased significantly to0.75, 0.97, and 0.52 D, respectively, compared to their baseline values.

Anterior best fit sphere (BFS) also had significant difference at 24-month follow-up compared to base line

evaluation. The central corneal thickness decreased significantly up to38 ? after 2 years.

Conclusion: Corneal collagen cross-linking is an effective treatment to stop the progression of keratoconusas

shown by reduced keratometry and improved vision.

Author Biography

Mitra Zamani1 , Asghar Heidarian2 , Mohammad Sadegh Mirdehghan3

1 Associate Professor, 2Tutor, 3Resident of Ophthalmology, Department of Ophthalmology, Imam Khomeini Hospital

and Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran




How to Cite

Mitra Zamani1 , Asghar Heidarian2 , Mohammad Sadegh Mirdehghan3. (2020). Two-Years Corneal Collagen Cross-Linking Outcomes in Patients with Keratoconus. Indian Journal of Forensic Medicine & Toxicology, 14(3), 2045–2051.