Characteristics Nanoparticle of Propolis Ethanol Extracts with Variations of Chitosan-Sodium Alginat

Abstract

Nanoencapsulation technology has many advantages, which include important roles in drug delivery and

protection of bioactive components that have perishable stability, one of which is polyphenol compounds.

Propolis which contains high levels of polyphenol compounds has been used as an antioxidant for various

diseases. By making nanoparticles from propolis, it can maintain the stability of polyphenol compounds

from propolis and increase the effect of treatment through optimal delivery. Nanoformulations containing

ethanol extract of propolis were absorbed by chitosan-sodium alginate using an ionotropic pre-gelation

method. Optimization is carried out at various concentrations of chitosan, namely 0.05%; 0.075%; 0.1% and

0.125% , with the use of the same sodium alginate concentration which is 0.0063%. Testing of nanoparticle

characteristics includes particle size and morphology and adsorption efficiency (EE) consisting of total

flavonoid and total polyphenol values. The increase in chitosan polymer is directly proportional to the

increase in particle size, but does not occur in the absorption efficiency value. The 0.05% chitosan formula

showed the absorption of polyphenol compounds at 99.41% with particle sizes of 259.12 nm